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ProteomicsRyR2 phosphorylation profile in PKP2cKO mice
The project aimed to investigate whether there are alterations in the phosphorylation status of the Ryanodine receptor 2 (RyR2) in the left atria of mice with a cardiac-specific knockout of PKP2, compared to wild-type mice.
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD052074 | Pride
Mouse Immunoprecipitation Ryr2 Phosphorylation 
ProteomicsPhosphorylation-dependent Interactome of Ryanodine Recep-tor Type-2 in the Heart
Background: Hyperphosphorylation of the calcium release channel/ryanodine receptor type 2 (RyR2) at serine 2814 (S2814) is associated with multiple cardiac diseases including atrial fibrilla-tion and heart failure. Despite recent advances, the molecular mechanisms driving pathological changes associ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-07 | PXD026350 | Pride
Ryr2 Heart Phosphorylation Interactome 
ProteomicsRYR2-deficient human hiPSC-derived cardiomyocyte protein expression
Creation of disease models utilizing hiPSCs in combination with CRISPR/Cas9 gene editing enable mechanistic insights into differential pharmacological responses. This allows translation of efficacy and safety findings from a healthy to a diseased state and provides a means to predict clinical outcom...
ORGANISM(S): Homo sapiens (Human) 
2024-06-20 | PXD052254 | Pride
Hipscs Human Ryr2 Lc-ms/ms Cell line 
TranscriptomicsIdentification of epigenetically silenced RYR2 by DNA methylation profiling in head and neck cancer squamous cell carcinoma
RYR2 promoter methylation and its impact on RYR2 gene expression was investigated in a cohort of patients with head and neck squamous cell carcinoma. The results suggest that impaired RYR2 function is a common event in HNSCC pathogenesis.
ORGANISM(S): Homo sapiens 
2021-06-11 | E-MTAB-7468 | biostudies-arrayexpress
TranscriptomicsIdentification of epigenetically silenced RYR2 by DNA methylation profiling in head and neck cancer squamous cell carcinoma part 2
RYR2 promoter methylation and its impact on RYR2 gene expression was investigated in a cohort of patients with head and neck squamous cell carcinoma. The results suggest that impaired RYR2 function is a common event in HNSCC pathogenesis.
ORGANISM(S): Homo sapiens 
2021-06-11 | E-MTAB-7478 | biostudies-arrayexpress
GenomicsAttempts to create transgenic mice carrying the Q3925E mutation in RyR2 Ca2+ binding site
Attempts to create transgenic mice carrying the Q3925E mutation in RyR2 Ca2+ binding site
PRJNA1157886 | ENA
UnknownCalmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814.
Not available
S-EPMC6791359 | biostudies-literature
UnknownCaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.
Not available
S-EPMC5026590 | biostudies-literature
TranscriptomicsAttempts to create transgenic mice carrying the Q3925E mutation in RyR2 Ca2+ binding site
Over 200 point mutations in ryanodine receptor (RyR2) of cardiac sarcoplasmic reticulum (SR) are known to associate with cardiac arrhythmia. We have already reported on the calcium signaling phenotype of a point mutation in RyR2 Ca2+ binding site Q3925E expressed in human stem-cell derived cardiomyo...
ORGANISM(S): Homo sapiens 
2024-12-31 | GSE276596 | GEO
GenomicsRyR2 inhibitor attenuates cardiac hypertrophy by downregulating TNF-α/NF-κB/NLRP3 signaling pathway
RyR2 inhibitor attenuates cardiac hypertrophy by downregulating TNF-α/NF-κB/NLRP3 signaling pathway
PRJNA766092 | ENA
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