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MetabolomicsPu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Metabolic syndrome (MS) is a common metabolic disorder characterized by obesity, insulin resistance, cardiovascular disease and gut microbiota dysbiosis. Pu-erh tea and its ingredient theabrownin have known functions on the reduction of body weight gain and fat accumulation. However, few studies sys...
2024-09-25 | MTBLS2594 | MetaboLights
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
TranscriptomicsPU.1 and C/EBPalpha synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers (expression data)
Unraveling the complexity of transcriptional programs coded by different cell types has been one of the central goals of cell biology. Using genome-wide location analysis, we examined how two different cell types generate different responses to the NF-kappaB signaling pathway. We showed that, after ...
ORGANISM(S): Homo sapiens 
2011-03-15 | E-GEOD-26868 | biostudies-arrayexpress
UnknownTranscription factor PU.1 is involved in the progression of glioma.
Not available
S-EPMC5795926 | biostudies-literature
UnknownPu-erh Tea Regulates Fatty Acid Metabolism in Mice Under High-Fat Diet.
Not available
S-EPMC6370627 | biostudies-literature
UnknownPositive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development.
Not available
S-EPMC11672030 | biostudies-literature
UnknownPU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway.
Not available
S-EPMC4410691 | biostudies-literature
UnknownEnhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation.
Not available
S-EPMC5874256 | biostudies-literature
ProteomicsA systemic view of microbial ecology in spontaneous fermentation of Chinese traditional pu-erh tea
To study the microbial functions, metaproteomes were extracted from 36 samples of fermented tea leaves and subjected to LC-MS/MS analyses. The MS/MS data were searched against the UniProt-protein database of the dominant microorganisms in the sample as identified by previous meta-barcoding analysis....
ORGANISM(S): Aspergillus Thermomyces Rasamsonia 
2019-01-03 | PXD012223 |
UnknownFolate-modified biomimetic nanovesicles loaded with a PU.1 inhibitor alleviate atherosclerosis by suppressing inflammation.
Not available
S-EPMC12797845 | biostudies-literature
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