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TranscriptomicsGene expression study in choroid plexus
The choroid plexus (CP) constitutes one of the blood–brain barriers – the blood cerebrospinal fluid barrier. It is formed by a monolayer of epithelial cells located within the brain ventricles and in addition to be responsible for the formation of the cerebrospinal fluid (CSF) is ideally positioned ...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-23714 | biostudies-arrayexpress
TranscriptomicsPortrait of early-onset breast cancer in Brazilian patients: germline mutation screening of BRCA1, BRCA2 and TP53 genes and tumor expression profiling
Differentially expressed genes between BRCA1/BRCA2 negative and positive mutation driven-tumors. Screening for germline mutations was performed in a cohort of 55 patients under the age of 35 years in the BRCA1, BRCA2, CHEK2 (c.del1,100C) and TP53 genes, and the respective tumors were investigated re...
ORGANISM(S): Homo sapiens 
2013-04-09 | E-GEOD-37126 | biostudies-arrayexpress
TranscriptomicsIdentification of genes related to local aggressiveness and metastatical potential in mesenchymal tumors
We analysed 102 sample of mesenchymal tumors of different histological type and biological behaviour. The aim of the study was to identify genes related to each characteristic analysed. We compared the gene expression profiles of 102 mesenchymal tumors with histological and clinical parameters. Tota...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-14541 | biostudies-arrayexpress
TranscriptomicsTransduction signaling signature of Wilms tumor revealed by parallel analysis of kidney differentiation
Precise regulation of transduction signaling pathways genes is crucial for correct differentiation of kidney cells and perturbation may lead to tumor onset. Wilms tumors (WT), or nephroblastoma, originates from the metanephric blastema cells, which were unable to complete the differentiation, result...
ORGANISM(S): Mus musculus 
2011-12-07 | E-GEOD-25965 | biostudies-arrayexpress
TranscriptomicsCo-expression network analysis from genes involved with neural-differentiation shows specific pattern in patients with schizophrenia
Schizophrenia is a severe and debilitating neuropsychiatric disorder with the involvement of genetic and environmental factors contributing to its pathogenesis. The specific role of the brain cell types in the disease remains uncovered due to the difficulties in accessing diseased tissue. This study...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-62105 | biostudies-arrayexpress
TranscriptomicsHOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis.
In order to determine the role of HOXB7 gene in cell lines derived from pancreatic ductal adenocarcinoma (MIA PaCa-2 e Capan-1), we performed its silencing utilizing the technique of RNA interference (RNAi). Total RNA derived from the inhibition as well as from parental cells was quantified in Bioan...
ORGANISM(S): Homo sapiens 
2013-07-26 | E-GEOD-46393 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of patients with schizophrenia, bipolar disorder and healthy controls
Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions, with a lifetime prevalence of about 1%. Both disorders have a neurodevelopment component, with onset of symptoms occurring most frequently during late adolescence or early adulthood. Genetic findings indicate the existen...
ORGANISM(S): Homo sapiens 
2014-10-11 | E-GEOD-62191 | biostudies-arrayexpress
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