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TranscriptomicsMurine pulmonary arterial smooth muscle cells: Wild-type vs. NOX1 deficiency (mRNA profiling)
NOX1 is a catalytic subunit of nonphagocytic NADPH oxidase, mainly localized to smooth muscle cells in the vasculature. We investigated the pathology underlying the pulmonary arterial hypertension-like phenotype demonstrated in mice deficient in the Nox1 gene (Nox1-KO). Spontaneous enlargement and h...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-42014 | biostudies-arrayexpress
TranscriptomicsMurine pulmonary arterial smooth muscle cells: Wild-type vs. NOX1 deficiency (miRNA profiling)
NOX1 is a catalytic subunit of nonphagocytic NADPH oxidase, mainly localized to smooth muscle cells in the vasculature. We investigated the pathology underlying the pulmonary arterial hypertension-like phenotype demonstrated in mice deficient in the Nox1 gene (Nox1-KO). Spontaneous enlargement and h...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-42015 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal subjects and IPAH patients to examine the effect of BMP-2 on pulmonary artery smooth muscle cells
Bone morphogenetic proteins (BMP) inhibit proliferation and induce apoptosis in pulmonary artery smooth muscle cells (PASMC) from normal subjects. Dysfunction of BMP signaling due to mutations in and/or downregulation of BMP receptors has been implicated in idiopathic pulmonary arterial hypertension...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-2559 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human aortic smooth muscle cells exposed to hypoxia
Systemic arterial smooth muscle cells are exposed to a broad range of oxygen concentrations under physiological conditions. Hypoxia can modulate the proliferative response of smooth muscle cells leading to speculation about its role in vasculogenesis, vascular remodelling and the pathogenesis of ar...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4725 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of mitochondria isolated from rat pulmonary arterial smooth muscle cells under normoxia and chronic hypoxia
Primary pulmonary arterial smooth muscle cells (PASMCs) were isolated from rat lungs by an arterial tracing method and cultured to passage 4. Cells were exposed to normoxia (21% O2) or hypoxia (1% O2) for 48 h. A mitochondria-enriched fraction was prepared from each culture and analysed by label-fre...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD083383 | Pride
Rat Hypoxia Mitochondria Cytochrome c oxidase Data-independent acquisition Pasmc Pulmonary arterial smooth muscle cell Cox4i2 
TranscriptomicsAcquired chromosome abnormalities in the lungs of patients with Pulmonary Arterial Hypertension (Illumina)
Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasi-neoplastic, with evidence of monoclonal...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-21097 | biostudies-arrayexpress
TranscriptomicsA critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target (TaqMan qPCR)
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed apoptosis. Downregulation of the BMPR2 gene along with activation of the transcription factor NFAT have been implicated in the mai...
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-21281 | biostudies-arrayexpress
TranscriptomicsEndothelial DNA methalytion signature in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a severe and incurable pulmonary vascular disease. One of the primary origins of PAH is pulmonary endothelial dysfunction leading to vasoconstriction, aberrant angiogenesis and smooth muscle cell proliferation, endothelial-to-mesenchymal transition, thrombosi...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-84395 | biostudies-arrayexpress
GenomicsDNA methylation signatures of pulmonary arterial smooth muscle cells in chronic thromboembolic pulmonary hypertension
DNA methylation signatures of pulmonary arterial smooth muscle cells in chronic thromboembolic pulmonary hypertension
PRJNA449913 | ENA
TranscriptomicsMurine pulmonary arterial smooth muscle cells: Wild-type vs. NOX1 deficiency
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-42016 | biostudies-arrayexpress
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