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Metabolomics2 lines of pulmonary artery smooth muscle cells metabolic profile (122 vs 3633C central metabolic profile)
Not available
ORGANISM(S): Ovis aries 
ST000180 | MetabolomicsWorkbench
TranscriptomicsEffects of BMPR2 Loss in Human Pulmonary Artery Endothelial Cells
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a proliferative endothelial cell phenotype, inflammation and pulmonary vascular remodeling. BMPR2 loss-of-function has been linked to pathologic plexiform lesions with obliteration of distal pulmonary arteries distal pulmonary...
ORGANISM(S): Homo sapiens 
2015-12-04 | E-GEOD-70456 | biostudies-arrayexpress
TranscriptomicsGene expression profiles based on Pulmonary Artery Pressures in Pulmonary Fibrosis
Pulmonary Hypertension (PH) is a frequent complication of Pulmonary Fibrosis (PF). PH can be seen in PF in the abscence of hypoxemia, irrespective of the degree of fibrosis. At the same time, a consistent number of patients with advanced PF never develop PH. The pathogenesis of PH secondary to PF re...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24988 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal subjects and IPAH patients to examine the effect of BMP-2 on pulmonary artery smooth muscle cells
Bone morphogenetic proteins (BMP) inhibit proliferation and induce apoptosis in pulmonary artery smooth muscle cells (PASMC) from normal subjects. Dysfunction of BMP signaling due to mutations in and/or downregulation of BMP receptors has been implicated in idiopathic pulmonary arterial hypertension...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-2559 | biostudies-arrayexpress
MetabolomicsCombined Mesenchymal Stem Cells and Metformin Therapy Modulates Key Macromolecular Pathways in Pulmonary Fibrosis: Evidence from Untargeted Metabolomics

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Current treatment options remain limited, driving interest in novel therapeutic approaches. Mesenchymal stem cells (MSCs) possess immunomodulatory and regenerative properties, while metformin, traditionally ...

2025-08-25 | MTBLS12893 | MetaboLights
ProteomicsProteomics analysis of lncRNA Snhg18 interacting proteins in pulmonary artery smooth muscle cells
To identify proteins that interact with Snhg18, we performed the RNA pull down assay followed by mass spectrometry in pulmonary artery smooth muscle cells.
ORGANISM(S): Mus musculus (Mouse) 
2026-05-13 | PXD070529 | Pride
Snhg18 Long non-coding rna Pulmonary artery smooth muscle cell 
TranscriptomicsTranscription profiling of human pulmonary artery endothelial cell culture treated with Chapel Hill Ultrafine particle
Epidemiology studies have linked exposure to pollutant particles to increased cardiovascular mortality and morbidity, however, the mechanism remains unknown. In this study, we hypothesized that the ultrafine fraction of ambient pollutant particles would cause endothelial cells dysfunction. We profi...
ORGANISM(S): Homo sapiens 
2009-05-02 | E-GEOD-4567 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of pulmonary artery in a rabbit model of pulmonary thromboembolism
Acute pulmonary thromboembolism (PTE) refers to the obstruction of the pulmonary artery or its branches by thrombus. Recent studies suggest that PTE-induced endothelium injury is the major physiological consequence of PTE, and PTE-induced endothelium injury can be used to stratify disease severity....
ORGANISM(S): Oryctolagus cuniculus 
2016-07-23 | E-GEOD-84738 | biostudies-arrayexpress
TranscriptomicsGene expression in tissues of Mus musculus with innate immunity stimulation
This is an investigation of whole genome gene expression level in tissues of mice stimulated by LPS, FK565 or LPS + FK565 in vivo and ex vivo. We show that parenteral administration of a pure synthetic Nod1 ligand, FK565, induces site-specific vascular inflammation in mice, which is prominent in aor...
ORGANISM(S): Mus musculus 
2011-03-01 | E-GEOD-20930 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pulmonary epithelial cells cultured in plasma from sickle cell disease acute chest syndrome and steady-state patients
Clinical variability in sickle cell disease (SCD) suggests a role for extra-erythrocytic factors in the pathogenesis of vasoocclusion. We hypothesized that one potential factor, endothelial dysfunction, results from induction of phenotypic changes by circulating factors in SCD patients. The database...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-1849 | biostudies-arrayexpress
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