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TranscriptomicsTranscription profiling of human normal subjects and IPAH patients to examine the effect of BMP-2 on pulmonary artery smooth muscle cells
Bone morphogenetic proteins (BMP) inhibit proliferation and induce apoptosis in pulmonary artery smooth muscle cells (PASMC) from normal subjects. Dysfunction of BMP signaling due to mutations in and/or downregulation of BMP receptors has been implicated in idiopathic pulmonary arterial hypertension...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-2559 | biostudies-arrayexpress
ProteomicsProteomics analysis of lncRNA Snhg18 interacting proteins in pulmonary artery smooth muscle cells
To identify proteins that interact with Snhg18, we performed the RNA pull down assay followed by mass spectrometry in pulmonary artery smooth muscle cells.
ORGANISM(S): Mus musculus (Mouse) 
2026-05-13 | PXD070529 | Pride
Snhg18 Long non-coding rna Pulmonary artery smooth muscle cell 
TranscriptomicsMurine pulmonary arterial smooth muscle cells: Wild-type vs. NOX1 deficiency (mRNA profiling)
NOX1 is a catalytic subunit of nonphagocytic NADPH oxidase, mainly localized to smooth muscle cells in the vasculature. We investigated the pathology underlying the pulmonary arterial hypertension-like phenotype demonstrated in mice deficient in the Nox1 gene (Nox1-KO). Spontaneous enlargement and h...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-42014 | biostudies-arrayexpress
TranscriptomicsMurine pulmonary arterial smooth muscle cells: Wild-type vs. NOX1 deficiency (miRNA profiling)
NOX1 is a catalytic subunit of nonphagocytic NADPH oxidase, mainly localized to smooth muscle cells in the vasculature. We investigated the pathology underlying the pulmonary arterial hypertension-like phenotype demonstrated in mice deficient in the Nox1 gene (Nox1-KO). Spontaneous enlargement and h...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-42015 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human aortic smooth muscle cells exposed to hypoxia
Systemic arterial smooth muscle cells are exposed to a broad range of oxygen concentrations under physiological conditions. Hypoxia can modulate the proliferative response of smooth muscle cells leading to speculation about its role in vasculogenesis, vascular remodelling and the pathogenesis of ar...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4725 | biostudies-arrayexpress
TranscriptomicsMicroarray to identify miR-143 targets in pulmonary artery smooth muscle cells.
Pulmonary artery smooth muscle cells were either mock transfected, transfected with scramble control or transfected with pre-miR-143. After 24 hours the cells were harvested with Qiazol and processed for a microarray experiment. The experiment was performed in order to identify potential targets o...
ORGANISM(S): Homo sapiens 
2015-06-26 | E-MTAB-3567 | biostudies-arrayexpress
TranscriptomicsAcquired chromosome abnormalities in the lungs of patients with Pulmonary Arterial Hypertension (Illumina)
Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasi-neoplastic, with evidence of monoclonal...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-21097 | biostudies-arrayexpress
TranscriptomicsGene expression profiles based on Pulmonary Artery Pressures in Pulmonary Fibrosis
Pulmonary Hypertension (PH) is a frequent complication of Pulmonary Fibrosis (PF). PH can be seen in PF in the abscence of hypoxemia, irrespective of the degree of fibrosis. At the same time, a consistent number of patients with advanced PF never develop PH. The pathogenesis of PH secondary to PF re...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24988 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of mitochondria isolated from rat pulmonary arterial smooth muscle cells under normoxia and chronic hypoxia
Primary pulmonary arterial smooth muscle cells (PASMCs) were isolated from rat lungs by an arterial tracing method and cultured to passage 4. Cells were exposed to normoxia (21% O2) or hypoxia (1% O2) for 48 h. A mitochondria-enriched fraction was prepared from each culture and analysed by label-fre...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD083383 | Pride
Rat Hypoxia Mitochondria Cytochrome c oxidase Data-independent acquisition Pasmc Pulmonary arterial smooth muscle cell Cox4i2 
GenomicsEffects of ferroptotic endothelial cell DAMPs on pulmonary artery smooth muscle cells
Effects of ferroptotic endothelial cell DAMPs on pulmonary artery smooth muscle cells
PRJNA1160921 | ENA
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