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MetabolomicsChronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study: Serum Lipidomics
The overall clinical study used a parallel-group, case-controlled study design in order to identify a biomarker or panel of biomarkers for the differentiation of subjects with mild to moderate COPD (GOLD stage I and II), asymptomatic current smokers, former smokers and never-smokers and to compare p...
2017-02-20 | MTBLS358 | MetaboLights
TranscriptomicsTranscription profiling of rat lung to investigate trauma hemorrhagic shock-induced lung injury: hemorrhage- and injury-associated genes
The etiology of trauma-hemorrhage shock-induced acute lung injury has been difficult to elucidate due, at least in part, to the inability of in vivo studies to separate the non-injurious pulmonary effects of trauma-hemorrhage from the tissue injurious ones. To circumvent this in vivo limitation, we...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6332 | biostudies-arrayexpress
GenomicsGenetics of Cerebral Hemorrhage with Anticoagulation (GOCHA)

This is a prospective, longitudinal cohort study of spontaneous ICH. Subjects were recruited from among consecutive patients ≥ 55 years old who presented with primary hemorrhage to the Massachusetts General Hospital or one of our off-site collaborators from 1999 to 2010. Potential subjects ...

phs000416.v1.p1 | EGA
UnknownUpdate on diffuse alveolar hemorrhage and pulmonary vasculitis.
Not available
S-EPMC3483562 | biostudies-literature
TranscriptomicsTranscription profiling of rat model of pumonary hypertension revals a multi- kinase inhibitor modulates pulmonary hypertension
Pulmonary hypertension (PH) and cancer pathophysiology share common signal transduction pathways leading to abnormal endothelial and smooth muscle cell interactions and angioproliferative vasculopathy. Sorafenib (Sor) a drug in clinical trials for cancer treatment, is an inhibitor of multiple kinase...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8134 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat model of pulmonary hypertension reveals Multi- Kinase Inhibitor Modulates Pulmonary Hypertension - Rodent Model 2
Pulmonary hypertension (PH) and cancer pathophysiology share common signal transduction pathways leading to abnormal endothelial and smooth muscle cell interactions and angioproliferative vasculopathy. Sorafenib (Sor) a drug in clinical trials for cancer treatment, is an inhibitor of multiple kinase...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8132 | biostudies-arrayexpress
UnknownPulmonary bleeding in racehorses: A gross, histologic, and ultrastructural comparison of exercise-induced pulmonary hemorrhage and exercise-associated fatal pulmonary hemorrhage.
Not available
S-EPMC9530536 | biostudies-literature
TranscriptomicsPulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed, carcinogenic environmental contaminants produced as a consequence of the incomplete combustion of fossil fuels. Benzo[a]pyrene (BaP) is a very extensively studied prototypical PAH. We recently reported a complete lack of change in micro...
ORGANISM(S): Mus musculus 
2011-10-03 | E-GEOD-24751 | biostudies-arrayexpress
TranscriptomicsChanges in cholesterol homeostasis and acute phase response following pulmonary exposure to multi-walled carbon nanotubes links carbon nanotube exposure to risk of cardiovascular disease
Adverse lung effects in rodents following pulmonary exposure to multi-walled carbon nanotubes (MWCNT) are well documented. However, systemic effects are less understood. Prospective epidemiological studies have shown increased cardiovascular disease risk after pulmonary exposure to airborne particle...
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-61366 | biostudies-arrayexpress
UnknownNeutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury.
Not available
S-EPMC11645157 | biostudies-literature
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