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ProteomicsPhysiological shear stress markedly alters the proteomic response to hypoxia in human pulmonary microvascular endothelial cells
Physiological shear stress, produced by blood flow, homeostatically regulates the phenotype of pulmonary endothelial cells exerting anti-inflammatory and anti-thrombotic actions and maintaining normal barrier function. In the pulmonary circulation hypoxia, due to high altitude or diseases such as CO...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD036260 | Pride
Shear stress Copd Human pulmonary microvascular endothelial cells Hypoxia 
ProteomicsTranscriptomics and proteomics revealed sex differences in human pulmonary microvascular endothelial cells
There is marked sexual dimorphism displayed in the onset and progression of pulmonary hypertension (PH). Females more commonly develop pulmonary arterial hypertension (PAH), however, females with PAH and other types of PH have better survival than males. Pulmonary microvascular endothelial cells pla...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD046787 | Pride
Sex differences Human pulmonary microvascular endothelial cells Hypoxia Pulmonary hypertension 
ProteomicsPulmonary microvascular endothelial cells support alveolar epithelial growth via bone morphogenetic protein 6 secretion
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and emphysema development, associated with enhanced tissue destruction and defective repair. Supporting cells in the alveolar niche play a crucial role in guiding the activation of alveolar epithelial pro...
ORGANISM(S): Homo sapiens (Human) 
2026-07-02 | PXD053755 | Pride
Bmp6 Pulmonary microvascular endothelial cells Copd 
TranscriptomicsTranscription profiling by array of mouse microvascular endothelial cells treated with FGF2
Effect of FGF2 on the transcriptional profile of microvascular endothelial cells
ORGANISM(S): Mus musculus 
2008-08-12 | E-MEXP-1467 | biostudies-arrayexpress
TranscriptomicsMultiple waves of transcriptome changes during extended hypoxic induction in human pulmonary microvascular endothelial cells
We profile the expression pattern of human pulmonary microvascular endothelial cells (HPMECs) at different time points of hypoxic stress. Through mRNA-seq, we identify functional waves of minor gene up-regulation at 8 and 24h hypoxia exposure followed by a massive wave of transcriptional activation ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-53510 | biostudies-arrayexpress
GenomicsPFKFB3 inhibits fructose metabolism in pulmonary microvascular endothelial cells
PFKFB3 inhibits fructose metabolism in pulmonary microvascular endothelial cells
PRJNA962089 | ENA
TranscriptomicsExpression data from BMP9-treated human dermal microvascular endothelial cells (HMVEC-D)
BMP9 signaling has been implicated in hereditary hemorrhagic telangiectasia and vascular remodeling, acting via the HHT target genes, endoglin and ALK1. This study sought to identify endothelial BMP9-regulated proteins that could affect the HHT phenotype. Gene ontology analysis of cDNA microarray da...
ORGANISM(S): Homo sapiens 
2012-09-19 | E-GEOD-40960 | biostudies-arrayexpress
GenomicsAssessment of OSMR dependency in pulmonary microvascular endothelial cells [NGS4630]
Assessment of OSMR dependency in pulmonary microvascular endothelial cells [NGS4630]
PRJNA1095503 | ENA
ProteomicsThe role of aging on endothelial cell-cell junctions and pulmonary microvascular permeability
Acute respiratory distress syndrome (ARDS) is a leading cause of intensive care unit (ICU) admissions and is associated with high short- and long-term mortality, particularly among elderly patients. Aging is a major risk factor for ARDS development and worsened outcomes, yet the mechanisms underlyin...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD065409 | Pride
Acute respiratory distress syndrome (ards) Endothelial barrier dysfunction Proteomics Inflammation Cytoskeleton Aging 
TranscriptomicsTranscriptomic analysis of microvascular response to carbon and photon irradiation
The aim of our study is to investigate and compare the effects of carbon and photon irradiation on microvascular endothelial cells. Therefore we irradiated human pulmonary microvascular endothelial cells (HPMEC) with either 2Gy Carbon or 6Gy Photon (bioequivalent doses) and performed microarray anal...
ORGANISM(S): Homo sapiens 
2023-11-02 | E-MEXP-3956 | biostudies-arrayexpress
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