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TranscriptomicsTET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-37365 | biostudies-arrayexpress
TranscriptomicsIsolation and expression profiling of circulating tumor cells in breast cancer patients
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-45965 | biostudies-arrayexpress
GenomicsNANOG metabolically reprograms tumor-initiating stem-like cells in oxidative phosphorylation and fatty acid metabolism
Stem cell markers such as NANOG have been implicated in various cancers; however, the functional contribution of NANOG to cancer pathogenesis has remained unclear. In the present study, we show that Toll-like receptor 4 (TLR4) signaling phosphorylates E2F1 to transactivate NANOG. Down-regulation of ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-68237 | biostudies-arrayexpress
TranscriptomicsLinker histone H1.2 establishes chromatin comapction and gene silencing through recognition of H3K27me3
Linker histone H1 is a protein component of chromatin and has been linked to chromatin compaction and global gene silencing.It has been sugegsted that H1 plays a significant role, regulating a relatively small number of genes. Here we show that H1.2- a variant of H1 subtype is recruited to chromati...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-68050 | biostudies-arrayexpress
TranscriptomicsIsolation and expression profiling of circulating tumor cells in breast cancer patients part 2
We developed a method to isolate pure circulating tumor cells (CTC). RNA from such CTCs isolated from the peripheral blood of metastatic breats cnacer patients and gene expression was performed using cDNAmicroarray. we used cDNA array to compare gene expression of CTCs with normal epithelial and b...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-45963 | biostudies-arrayexpress
TranscriptomicsIsolation and expression profiling of circulating tumor cells in breast cancer patients part 1
We developed a method to isolate pure circulating tumor cells (CTC). RNA from such CTCs isolated from the peripheral blood of metastatic breast cancer patients and gene expression was performed using cDNAmicroarray. we used cDNA array to compare gene expression of CTCs with normal epithelial and b...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-45962 | biostudies-arrayexpress
TranscriptomicsIsolation and expression profiling of circulating tumor cells in breast cancer patients part 3
We developed a method to isolate pure circulating tumor cells (CTC). RNA from such CTCs isolated from the peripheral blood of metastatic breats cnacer patients and gene expression was performed using cDNAmicroarray. we used cDNA array to compare gene expression of CTCs with normal epithelial and b...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-45964 | biostudies-arrayexpress
TranscriptomicsTET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma (DNA methylation)
Genome wide DNA methylation profiling of patient samples with TET2 mutations and Wild type TET2 status . The Illumina Infinium HumanMethylation 450_15017482_v.1.1 was used to obtain DNA methylation profiles across approximately 482,421 CpGs in fresh frozen lymphoma samples. Samples include 19 TET2...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-37362 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of TET2 wild type and TET2 mutant patients with diffuse large B-cell derived lymphoma
Global gene expression in TET2 mutant and Wild type patients. We performed an integrated analysis of global DNA methylation and gene expression data to investigate the effects of DNA hypermethylation on gene expression. Total RNA was isolated from 4 TET2mut and 5 TET2wt were isolated using standard...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-37363 | biostudies-arrayexpress
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