Sort   by:  
 Page size 
MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
MetabolomicsPithecellobium clypearia ameliorates ulcerative colitis through regulation of purine metabolism and gut microbiota

Background: Pithecellobium clypearia (PC) is a traditional Chinese medicine with anti-inflammatory effects. However, the therapeutic efficacy and underlying mechanisms of PC in ulcerative colitis (UC) remain unclear.

Objective: This study applied an integrated microbiome-meta...

2026-06-26 | MTBLS14856 | MetaboLights
MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
MetabolomicsHfq Regulates Efflux Pump Expression and Purine Metabolic Pathway to Increase the Trimethoprim Resistance in Aeromonas veronii

Aeromonas veronii (A. veronii) is a zoonotic pathogen. It causes clinically a variety of diseases such as dysentery, bacteremia, and meningitis. And it also brings huge losses to aquaculture. A. veronii has been documented as a multiple antibiotic resistant bacterium. Hfq (host factor for RNA bac...

2020-02-19 | MTBLS1411 | MetaboLights
TranscriptomicsMetabolic Reprogramming During Purine Stress in the Protozoan Pathogen Leishmania donovani
The ability of Leishmania to survive in their insect or mammalian host is dependent upon an ability to sense and adapt to changes in the microenvironment. However, little is known about the molecular mechanisms underlying the parasite response to environmental changes, such as nutrient availability....
ORGANISM(S): Leishmania donovani 
2014-02-01 | E-GEOD-48394 | biostudies-arrayexpress
MetabolomicsPurine and TCA measurements in salt sensitive (SS) hypertension
Not available
ORGANISM(S): Rattus norvegicus 
ST000834 | MetabolomicsWorkbench
ModelsCurto1998 - purine metabolism
Curto1998 - purine metabolism This is a purine metabolism model that is geared toward studies of gout. The model uses Generalized Mass Action (GMA; i.e. power law) descriptions of reaction rate laws. Such descriptions are local approximations that assume indepe...
2024-09-02 | BIOMD0000000015 | BioModels
TranscriptomicsThe purine metabolite allantoin enhances abiotic stress tolerance through synergistic activation of abscisic acid metabolism
Purine catabolism is regarded as a housekeeping function that remobilizes nitrogen for plant growth and development. However, emerging evidence suggests that certain purine metabolites might contribute to stress protection of plants. Here, we show that in Arabidopsis, the intermediary metabolite all...
ORGANISM(S): Arabidopsis thaliana 
2014-01-16 | E-GEOD-44922 | biostudies-arrayexpress
MetabolomicsIrradiation causes alterations of polyamine, purine and sulfur metabolism in red blood cells and multiple organs (Prestool)
Not available
ORGANISM(S): Mus musculus 
ST002033 | MetabolomicsWorkbench
MetabolomicsIrradiation causes alterations of polyamine, purine and sulfur metabolism in red blood cells and multiple organs (Liver)
Not available
ORGANISM(S): Mus musculus 
ST002037 | MetabolomicsWorkbench
Sort   by:  
 Page size