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Insulin resistance (IR) underpins the relationship between obesity and its associated metabolic disorders. Negative energy balance alleviates IR rapidly, though the mechanism remains unclear. Here, we show that in obese mice, IR can be reversed by calorie reduction (CR) within a day. In the liver, i...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD067874 | Pride
Notch signaling is essential for proper lens development, however the specific requirements of individual Notch receptors has not been previously investigated. Here we report the lens phenotypes of Notch2 conditionally mutant mice, which exhibited severe microphthalmia, reduced pupillary openings, d...
ORGANISM(S): Mus musculus 
Detection of the altered expression of inflammation associated genes in patients’ blood can provide information regarding the stage of atherosclerotic plaque without undergoing invasive procedures. In the current study, the expression levels of mRNAs within the early stage and advanced stage atheros...
ORGANISM(S): Homo sapiens 
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