Sort   by:  
 Page size 
TranscriptomicsEffect of phenobarbital on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis
The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital (PB) on gene transcription. To investigate the relative role of CAR and PXR in the induction response, cDNA arrays were generated containing 120 genes which are known to b...
ORGANISM(S): Mus musculus 
2008-08-23 | E-GEOD-12489 | biostudies-arrayexpress
TranscriptomicsEffect of TCPOBOP on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis
The nuclear receptor CAR (constitutive androstane receptor) mediates the effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) on gene transcription. To investigate the relative role of CAR and also PXR in the induction response, cDNA arrays were generated containing 120 (Sterolgene V1) ...
ORGANISM(S): Mus musculus 
2008-08-23 | E-GEOD-12509 | biostudies-arrayexpress
TranscriptomicsEffect of PCN on CAR and PXR regulated genes involved in circadian rhythm, drug metabolism and cholesterol homeostasis
The nuclear receptor PXR (Pregnane X rreceptor) mediates the effects of pregnenolone-16alpha-carbonitrile (PCN) on gene transcription. The relative role of PXR and also CAR to the induction response by PCN was studied on cDNA arrays containing 320 (Steroltalk V2) genes (genes involved in cyrcadian r...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-12537 | biostudies-arrayexpress
TranscriptomicsPhenobarbital and TCPOBOP effects on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis
This SuperSeries is composed of the following subset Series: GSE12489: Effect of phenobarbital on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis GSE12509: Effect of TCPOBOP on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis Ref...
ORGANISM(S): Mus musculus 
2008-08-23 | E-GEOD-12529 | biostudies-arrayexpress
TranscriptomicsA Novel Statistical Algorithm for Gene Expression Analysis Differentiates PXR-Dependent and Independent Mechanisms of Toxicity
The objective of the present study is to examine the potential role of the pregnane x receptor (PXR) in mice treated with an small molecule inhibitor for beta-secretase (CMP013) Two groups of mice, C57Bl/6 (PXR+/+) and PXR-knockout C57Bl/6NTac (PXR-/-), were administered either CMP013 or vehicle. Th...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-23780 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of liver from wild type and PXR-null mice treated with PCN
Many environmentally-relevant chemicals and drugs activate the nuclear receptor pregnane X receptor (PXR). Activation of PXR can lead to increases in liver weight in part through hepatocyte replication similar to a large number of compounds that activate other nuclear receptors such as the peroxiso...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-55746 | biostudies-arrayexpress
TranscriptomicsGenome wide comparison of the inducible transcriptomes of CAR, PXR and PPARα in primary human hepatocytes
To identify the CAR-, PXR- and PPARα-specific genome-wide expression changes, hepatocyte cultures from six individual donors were treated with the prototypical ligands for CAR (CITCO), PXR (rifampicin) and PPARα (WY14,643) as well as DMSO (vehicle control). Afterwards, the mRNA expression in these...
ORGANISM(S): Homo sapiens 
2016-03-24 | E-GEOD-76148 | biostudies-arrayexpress
GenomicsEffects of PXR activation on the macrophage transcriptome
Effects of PXR activation on the macrophage transcriptome
PRJNA607989 | ENA
GenomicsAtorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis
Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis
PRJNA1265605 | ENA
ProteomicsRat liver treated by PCN
The combination analyses of transcriptomics, proteomics, phosphoproteomics, and metabolomics in rat liver after repeated oral doses of PXR agonist, PCN, for 7 days were conducted to understand the roles for PXR on non-genotoxic signaling and energy homeostasis. mRNA and proteins in homogenate supern...
ORGANISM(S): Rattus Rattus (black Rat) 
2018-01-01 | PXD006305 | JPOST Repository
Sort   by:  
 Page size