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MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
ProteomicsTailored cofactor traps for the in situ detection of hemithioacetal-forming pyridoxal kinases
Pyridoxal kinases (PLK) are crucial enzymes for the biosynthesis of pyridoxal phosphate, an important cofactor in a plethora of enzymatic reactions. The evolution of these enzymes resulted in different catalytic designs. In addition to the active site, the relevance of a cysteine, embedded within a ...
ORGANISM(S): Escherichia coli Enterococcus faecalis (Streptococcus faecalis) Staphylococcus aureus 
2020-12-23 | PXD021791 | Pride
Pyridoxal E. faecalis Pyridoxal kinase E. coli P. aeruginosa S. aureus Lc-ms/ms 
GenomicsMus musculus
Natural Product P57 Induces Hypothermia through Targeting Pyridoxal Kinase
PRJNA1056925 | ENA
UnknownCrystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases.
Not available
S-EPMC1482971 | biostudies-literature
UnknownCrystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition.
Not available
S-EPMC3412620 | biostudies-literature
UnknownPyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission.
Not available
S-EPMC7777086 | biostudies-literature
UnknownNatural product P57 induces hypothermia through targeting pyridoxal kinase.
Not available
S-EPMC10522591 | biostudies-literature
UnknownChemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome.
Not available
S-EPMC3470933 | biostudies-literature
UnknownNew Insights Into Pyridoxal Kinase Inhibitors and Their Antileukemic Effects.
Not available
S-EPMC10693352 | biostudies-literature
UnknownCrystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation.
Not available
S-EPMC2204131 | biostudies-literature
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