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ProteomicsCustomizing functionalized cofactor mimics to study the human pyridoxal 5'-phosphate-binding proteome
Here we apply functionalized cofactor derivatives to study vitamin B6-dependent enzymes in human cells. We are able to cover for a large fraction of the pyridoxal 5'-phosphate-binding proteome (PLP-ome) and validate our results exemplarily for two PLP-DEs. One of those, named pyridoxal 5'-phosphate ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-27 | PXD014771 | Pride
Pyridoxal-probe Vitamin b6 antagonist Pyridoxal 5'-phosphate 
ProteomicsTailored cofactor traps for the in situ detection of hemithioacetal-forming pyridoxal kinases
Pyridoxal kinases (PLK) are crucial enzymes for the biosynthesis of pyridoxal phosphate, an important cofactor in a plethora of enzymatic reactions. The evolution of these enzymes resulted in different catalytic designs. In addition to the active site, the relevance of a cysteine, embedded within a ...
ORGANISM(S): Escherichia coli Enterococcus faecalis (Streptococcus faecalis) Staphylococcus aureus 
2020-12-23 | PXD021791 | Pride
Pyridoxal E. faecalis Pyridoxal kinase E. coli P. aeruginosa S. aureus Lc-ms/ms 
ProteomicsMining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics
Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in numerous essential cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification based on sequence homology challenging. This ...
ORGANISM(S): Staphylococcus aureus 
2018-10-17 | PXD006483 | Pride
Pyridoxal phosphate Cofactor Vitamin b6 
ProteomicsTailored pyridoxal probes unravel novel cofactor-dependent targets and antibiotic hits in critical bacterial pathogens
Unprecedented bacterial targets are urgently needed for the development of novel antibiotics to overcome the current resistance crisis. Challenges include the limited uptake of compounds as well as prioritizing proteins for their druggability and functional relevance. Especially, the wealth of uncha...
ORGANISM(S): Pseudomonas aeruginosa Escherichia coli Staphylococcus aureus 
2022-08-12 | PXD029832 | Pride
Enzyme characterization Antibiotic compound screening Chemical proteomics Pyridoxal phosphate dependent enzymes 
UnknownBioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate.
Not available
S-EPMC3439857 | biostudies-literature
UnknownCrystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases.
Not available
S-EPMC1482971 | biostudies-literature
GenomicsMus musculus
Natural Product P57 Induces Hypothermia through Targeting Pyridoxal Kinase
PRJNA1056925 | ENA
ProteomicsBiochemical and proteomic studies on pyridoxal 5'-phosphate-binding protein (PLPBP)
Structural and proteomic investigations on conserved PLPBP.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD015984 | Pride
Prosc Plpbp Pyridoxal 
UnknownChemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.
Not available
S-EPMC3357107 | biostudies-literature
UnknownSLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation.
Not available
S-EPMC11760969 | biostudies-literature
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