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MetabolomicsMembrane lipid as cofactor of cargo uptake and release by box-like lipid transfer proteins
Lipid transfer proteins (LTPs) shuttle their cargo lipids between cellular membranes. LTPs facilitate the costly extraction of a lipid from a donor membrane, and its delivery into the acceptor membrane, but the mechanisms remain poorly understood. We combined extensive molecular dynamics simulations...
2026-10-06 | MTBLS15933 | MetaboLights
ProteomicsCustomizing functionalized cofactor mimics to study the human pyridoxal 5'-phosphate-binding proteome
Here we apply functionalized cofactor derivatives to study vitamin B6-dependent enzymes in human cells. We are able to cover for a large fraction of the pyridoxal 5'-phosphate-binding proteome (PLP-ome) and validate our results exemplarily for two PLP-DEs. One of those, named pyridoxal 5'-phosphate ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-27 | PXD014771 | Pride
Pyridoxal-probe Vitamin b6 antagonist Pyridoxal 5'-phosphate 
ProteomicsMining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics
Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in numerous essential cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification based on sequence homology challenging. This ...
ORGANISM(S): Staphylococcus aureus 
2018-10-17 | PXD006483 | Pride
Pyridoxal phosphate Cofactor Vitamin b6 
UnknownT cell subtype profiling measures exhaustion and predicts anti-PD-1 response.
Not available
S-EPMC8789795 | biostudies-literature
TranscriptomicsCofactor-mediated Restriction of GATA-1 Chromatin Occupancy Coordinates Lineage-specific Gene Expression
This SuperSeries is composed of the following subset Series: GSE35644: Genome-wide analysis of the role of FOG-1 in GATA-1 chromatin occupancy GSE35695: Differential gene regulation by disease-associated mutants of GATA-1 during megakaryocyte differentiation Refer to individual Series
ORGANISM(S): Mus musculus 
2012-07-29 | E-GEOD-35708 | biostudies-arrayexpress
ProteomicsProteomics data reveal the effects of the non-natural cofactor nicotinamide cytosine dinucleotide on Escherichia coli
Nicotinamide adenine dinucleotide is an ubiquitous cofactor in cells. Non-natural cofactor or biomimetic cofactors have attracted great attention on account of their low cost, high stability and the application of efficient synthesis. Nicotinamide cytosine dinucleotide is reported as a non-natural ...
ORGANISM(S): Escherichia Coli 
PXD064813 |
ClinicalPhase III Randomized Study of 5-FU, CoFactor, and Avastin vs. 5-FU, LV and Avastin for First-Line Colorectal Cancer.
To compare the progression-free survival time (PFS) in patients treated with 5-FU modulated with CoFactor (plus bevacizumab) to 5-FU modulated with leucovorin (plus bevacizumab) in patients with Metastatic Colorectal Cancer.
2029777 | ecrin-mdr-crc
GenomicsRegulation of respiratory complex I assembly by FMN cofactor targeting
Regulation of respiratory complex I assembly by FMN cofactor targeting
PRJNA1047500 | ENA
TranscriptomicsRNA-seq of high grade serous ovarian cancer samples stratified by progression free survival
The purpose of the experiment was to determine an immune profile consisting of immune genes and cell types in high grade serous ovarian cancer tissue from patients with various lengths of progression free survival. Formalin fixed paraffin embedded (FFPE) tissue was screened for 80% cellularity and 2...
ORGANISM(S): Homo sapiens 
2021-11-02 | E-MTAB-9743 | biostudies-arrayexpress
TranscriptomicsOlig1 is a Smad cofactor involved in cell motility induced by transforming growth factor-b
Transforming growth factor (TGF)-β plays crucial roles in embryonic development and adult tissue homeostasis by eliciting various cellular responses in target cells. TGF-β signaling is principally mediated through receptor-activated Smad proteins, which regulate expression of target genes in coope...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46405 | biostudies-arrayexpress
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