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UnknownA fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status.
Not available
S-EPMC7061904 | biostudies-literature
ProteomicsCustomizing functionalized cofactor mimics to study the human pyridoxal 5'-phosphate-binding proteome
Here we apply functionalized cofactor derivatives to study vitamin B6-dependent enzymes in human cells. We are able to cover for a large fraction of the pyridoxal 5'-phosphate-binding proteome (PLP-ome) and validate our results exemplarily for two PLP-DEs. One of those, named pyridoxal 5'-phosphate ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-27 | PXD014771 | Pride
Pyridoxal-probe Vitamin b6 antagonist Pyridoxal 5'-phosphate 
ProteomicsChemical Proteomics Enhances the Understanding of 2AA Stress in Salmonella enterica
Pyridoxal 5’phosphate (PLP) is an essential cofactor for enzymes that catalyze diverse reactions in central metabolism. 2-aminoacrylate (2AA) is a reactive enamine and an obligate catalytic intermediate in some PLP-mediated reactions. In the absence of the enamine/imine deaminase RidA, Salmonella en...
ORGANISM(S): Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
2025-05-24 | PXD060390 | Pride
2-aminoacrylate Pyridoxal-phosphate-dependent enzymes Plp Chemical proteomics Rida 
UnknownCustomizing Functionalized Cofactor Mimics to Study the Human Pyridoxal 5'-Phosphate-Binding Proteome.
Not available
S-EPMC6876276 | biostudies-literature
UnknownBiocatalytic asymmetric aldol addition into unactivated ketones.
Not available
S-EPMC11611667 | biostudies-literature
UnknownNatural product P57 induces hypothermia through targeting pyridoxal kinase.
Not available
S-EPMC10522591 | biostudies-literature
ProteomicsTailored pyridoxal probes unravel novel cofactor-dependent targets and antibiotic hits in critical bacterial pathogens
Unprecedented bacterial targets are urgently needed for the development of novel antibiotics to overcome the current resistance crisis. Challenges include the limited uptake of compounds as well as prioritizing proteins for their druggability and functional relevance. Especially, the wealth of uncha...
ORGANISM(S): Pseudomonas aeruginosa Escherichia coli Staphylococcus aureus 
2022-08-12 | PXD029832 | Pride
Enzyme characterization Antibiotic compound screening Chemical proteomics Pyridoxal phosphate dependent enzymes 
UnknownA continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.
Not available
S-EPMC3135573 | biostudies-literature
UnknownSolution-State (17)O Quadrupole Central-Transition NMR Spectroscopy in the Active Site of Tryptophan Synthase.
Not available
S-EPMC4752203 | biostudies-literature
UnknownChemical proteomics enhances the understanding of 2AA stress in <i>Salmonella enterica</i>.
Not available
S-EPMC12172467 | biostudies-literature
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