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ProteomicsOptimized sample preparation, data processing of data-independent acquisition methods for the robust quantification of trace-level host cell protein impurities in drug products
In this study, we developed powerful and reproducible MS-based analytical workflows coupling optimized and efficient sample preparations, library-free DIA acquisition method and stringent validation criteria. The performances of several preparation protocols and DIA versus classical DDA were evaluat...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-10-19 | PXD019668 | Pride
Host cell proteins (hcp) Quantification Data-independent analysis (dia) Mass spectrometry Sample preparation 
ProteomicsThe translation release factor methyltransferase Mtq2-Trm112 is required for ribosome biogenesis
The Mtq2-Trm112 methyltransferase is known to modify the translational eukaryotic release factor eRF1 on the glutamine side chain of a universally conserved GGQ motif, which is essential to translation termination. The exact role of eRF1 methylation remains unknown. As the deletion of MTQ2 leads to ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-10-12 | PXD018733 | Pride
Rna processing Ribosome Translation Methyltransferase 
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