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MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
UnknownThe Chronic Conditions Care Collaborative (4C Collaborative): A Platform for Improving Diabetes and Heart Disease Outcomes in Rural South Carolina.
Not available
S-EPMC11562265 | biostudies-literature
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
ProteomicsAcclimatization of Methylocystis to inhibitory NH4+ levels by multiple proteomic and metabolic response mechanisms
High NH4+ load is known to competitively inhibit bacterial methane oxidation. This is due to a competition between CH4 and NH4+/NH3 for the active site of particulate methane monooxygenase (pMMO), which converts CH4 to CH3OH. Here, we combined growth experiments with global proteomics to elucidate t...
ORGANISM(S): Methylocystis sp. SC2 
2022-09-19 | PXD032347 | Pride
Methylocystis sp. strain sc2 
ProteomicsDiabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischaemia
The bioactive lipid intermediate palmitoyl CoA (PCoA) can inhibit mitochondrial ADP/ATP transport, though the physiological relevance of this regulation remains unclear. We questioned whether myocardial ischaemia was a pathological setting in which PCoA regulation of ADP/ATP transport would be bene...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-17 | PXD024500 | Pride
Pcoa Ischemia 
TranscriptomicsBrd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release
Distal enhancers characterized by H3K4me1 mark play critical roles in developmental and transcriptional programs. However, potential roles of specific distal regulatory elements in regulating RNA Polymerase II (Pol II) promoter-proximal pause release remain poorly investigated. Here we report that a...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-51633 | biostudies-arrayexpress
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
UnknownAntibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river.
Not available
S-EPMC2876458 | biostudies-literature
UnknownImproving uptake of telemedicine (phone/video consult): methods and lessons learnt.
Not available
S-EPMC11977467 | biostudies-literature
UnknownThe C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity.
Not available
S-EPMC10033314 | biostudies-literature
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