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MetabolomicsEffect of L-carnitine administration on lipid and metabolite content in sheep infraspinatus muscle after tendon release
Metabolites and lipid species were measured using ultrahigh performance lipid chromatography – tandem mass spectrometry in biopsies of infraspinatus muscle after 2 weeks of tendon release in the operated and contralateral muscle. A group of animals received oral treatment with L-carnitine.
2020-07-20 | MTBLS1490 | MetaboLights
MetabolomicsChanges in L-phenylalanine concentration reflect and predict response to anti-PD-1 treatment combined with chemotherapy in patients with non-small cell lung cancer
Chemotherapy combined with checkpoint blockade antibodies targeting programmed cell death protein (PD-1) has achieved remarkable success in non-small cell lung cancer (NSCLC). However, few patients benefit from long-term treatment. Therefore, biomarkers capable of guiding the optimal therapeutic sel...
2025-06-16 | MTBLS11232 | MetaboLights
MetabolomicsBilophila wadsworthia inhibits lifestyle intervention response in Gestational Diabetes Mellitus via L-glutamine regulation

Fecal samples were collected from 26 pregnant women with gestational diabetes mellitus (GDM) prior to and following a lifestyle intervention study, and subsequently analyzed using untargeted metabolomics.

2026-04-16 | MTBLS13807 | MetaboLights
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
TranscriptomicsNext generation sequencing of Coccinella septempunctata L. with non-diapause, diapause, and diapause-terminated states
The most common ladybird beetle, Coccinella septempunctata L., is an excellent predator of crop pests such as aphids and white flies, and it shows a wide range of adaptability, a large appetite and a high reproductive ability. In this study, we collected female adults in three different states, i.e...
ORGANISM(S): Coccinella septempunctata 
2016-06-01 | E-GEOD-75645 | biostudies-arrayexpress
ProteomicsComparative membrane-associated proteome of Leishmania (Leishmania) infantum and L.(L.) amazonensis
Protozoan parasites of the genus Leishmania are causative agents of leishmaniasis, a wide range of diseases affecting 12 million people worldwide. The species L. (L.) infantum and L. (L.) amazonensis are causative agents of visceral and cutaneous leishmaniasis, respectively. Most proteome analyses o...
ORGANISM(S): Leishmania infantum JPCM5 Leishmania mexicana 
2022-02-11 | PXD013087 | Pride
Label free proteomics Plasma membrane proteins Leishmania (leishmania) infantum Leishmania (leishmania) amazonensis 
MetabolomicsLC-MS untargeted approach showed that methyl jasmonate application on Vitis labrusca L. grapes increases phenolics at subtropical Brazilian regions

Vitis labrusca L. grapes are largely cultivated in Brazil, but the tropical climate affect negatively the phenols content, especially anthocyanin. Therefore, researches are focusing on increase grape phenols content; with methyl jasmonate application (MeJa) considered a good alternative.

T...

2020-05-26 | MTBLS784 | MetaboLights
ProteomicsSystematic analysis of lysine 2-hydroxyisobutyrylation in Rheum palmatum L． leaves
Lysine 2-hydroxyisobutyrylation (Khib) is a recently discovered posttranslational modification (PTM). Its structure characterization and function illustration have been reported in some species. However, the study of Khib in plant species is still relatively limited.Rheum palmatum L. is a global imp...
ORGANISM(S): Rheum palmatum 
2021-05-29 | PXD026307 | Pride
Lc-ms/ms Lysine 2-hydroxyisobutyrylation Rheum palmatum l 
MetabolomicsThe Cd-tolerance of pepper (Capsicum annuum L.) is linked with rhizosphere bacterial community composition and rhizosphere soil metabolites profiles

Cadmium (Cd) poses a serious threat to plant growth, so the selection and breeding of Cd-tolerant pepper cultivars is an effective method to reduce Cd hazards. This study identified C. annuum G03 as a Cd-tolerant cultivar, evidenced by its superior leaf physiological activity under Cd stress comp...

2025-10-23 | MTBLS13200 | MetaboLights
MetabolomicsDetoxification metabolic adaptation of Bombyx mori to artificial diet and functional study of key detoxification gene BmGSTd2

The exceptional adaptability of insects to diverse food sources is central to their survival and evolutionary success. However, the molecular mechanisms underlying this rapid adaptation remain largely uncharacterized. In this study, adaptive phenotypic, transcriptomic, and metabolomic differences...

2026-01-27 | MTBLS13782 | MetaboLights
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