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ProteomicsInegrative Proteomic Analysis Reveals the Cytaskeleton Regulation and Mtophagy Diference Between ischemicCardiomyopathy and Dilated Cardiomyopathy
Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are the two primary etiologies of end-stage heart failure. However, there remains a dearth of comprehensive understanding the global perspective and the dynamics of the proteome and phosphoproteome in ICM and DCM, which hinders the profo...
ORGANISM(S): Homo Sapiens 
2025-06-18 | PXD065145 |
ProteomicsSIRT2 regulates extracellular vesicle-mediated liver-bone communication
The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 expression is increased in aged mice and elderly humans. Liver-specific SIRT2 deficiency inhibits ...
ORGANISM(S): Mus Musculus 
2023-03-27 | PXD041145 |
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