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ProteomicsInegrative Proteomic Analysis Reveals the Cytaskeleton Regulation and Mtophagy Diference Between ischemicCardiomyopathy and Dilated Cardiomyopathy
Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are the two primary etiologies of end-stage heart failure. However, there remains a dearth of comprehensive understanding the global perspective and the dynamics of the proteome and phosphoproteome in ICM and DCM, which hinders the profo...
ORGANISM(S): Homo Sapiens 
2025-06-18 | PXD065145 |
ProteomicsSIRT2 regulates extracellular vesicle-mediated liver-bone communication
The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 expression is increased in aged mice and elderly humans. Liver-specific SIRT2 deficiency inhibits ...
ORGANISM(S): Mus Musculus 
2023-03-27 | PXD041145 |
ProteomicsThyroid cancer ATC-PDTC-PTC-N FFPE 4D-DIA proteomics
We performed 4D-DIA proteomic profiling on formalin-fixed paraffin-embedded (FFPE) thyroid tissues, covering anaplastic thyroid carcinoma (ATC), poorly differentiated thyroid carcinoma (PDTC), papillary thyroid carcinoma (PTC), and matched normal (N) controls. Using the timsTOF Pro platform with ion...
ORGANISM(S): Homo Sapiens 
2025-12-21 | PXD068266 |
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