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ProteomicsCell type resolved liver proteomics
Parenchymatous organs consist of multiple cell types, primarily defined as parenchymal cells (PCs) and nonparenchymal cells (NPCs). The cellular characteristics of these organs are not well understood. Proteomic studies facilitate the resolution of the molecular details of different cell types in or...
ORGANISM(S): Mus Musculus 
2017-04-20 | PXD008430 |
ProteomicsHuman Plasma Proteome with Three-dimensional Strategies by Highresolution Quadrupole Orbitrap Mass Spectrometry
Five three-dimensional strategies combining HAP depletion (the 1st dimension) and protein fractionation (the 2nd dimension), followed by LC-MS/MS analysis (the 3rd dimension) were developed and compared for human plasma proteome profiling. Pros and cons of the five strategies are discussed for two i...
ORGANISM(S): Homo Sapiens 
2017-06-20 | PXD008441 |
MetabolomicsLong-term low-dose ionizing radiation induced chromosome-aberration-specific metabolic phenotype changes in radiation workers

Long-term low-dose ionizing radiation (LLIR) widely exists in human life and has been confirmed to have potential pathogenic effects on cancer and cardiovascular diseases. However, it is technically and ethically unfeasible to explore LLIR-induced phenotypic changes in the human cohort, leading t...

2022-04-07 | MTBLS3854 | MetaboLights
Proteomics,MultiomicsCHPP chr 1,8,20 proteome dataset using the HCC cell lines of Hep3B and MHCC97H, instrument is AB5600, part 3 of 3
The fresh cells as described above were harvested and lysed in buffer containing 8 M Urea, 50 mM NH4HCO3 and 5 mM IAA. The total cell lysates were centrifuged with 12,000 g for 10 min at 4 degrees Celsius to remove cell debris, and 1.5 mg proteins for each cell line were followed by sequential in-so...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-20 | MSV000080256 | MassIVE
Proteomics,MultiomicsCHPP chr 1,8,20 proteome dataset using the HCC cell lines of MHCC97H and HCCLM3, instrument is Q Exactive, part 1 of 3
The fresh cells as described above were harvested and lysed in buffer containing 8 M Urea, 50 mM NH4HCO3 and 5 mM IAA. The total cell lysates were centrifuged with 12,000 g for 10 min at 4 degrees Celsius to remove cell debris, and 1.5 mg proteins for each cell line were followed by sequential in-s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-20 | MSV000080255 | MassIVE
Proteomics,MultiomicsCHPP chr 1,8,20 proteome dataset using the HCC cell lines of Hep3B and MHCC97H, instrument is Q Exactive, part 2 of 3
The fresh cells as described above were harvested and lysed in buffer containing 8 M Urea, 50 mM NH4HCO3 and 5 mM IAA. The total cell lysates were centrifuged with 12,000 g for 10 min at 4 degrees Celsius to remove cell debris, and 1.5 mg proteins for each cell line were followed by sequential in-so...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-20 | MSV000080254 | MassIVE
ProteomicsAn Orthogonal Extraction Workflow for High-Depth Plasma Proteomics with Metabolomic Compatibility from Low Microliter-Scale Samples
Herein, we report an orthogonal extraction workflow that achieves enhanced proteomic profiling depth while preserving metabolomic compatibility from a mere 10 µL of plasma. We demonstrate that a ternary solvent mixture (TSM) of methanol, acetonitrile, and acetone exhibits distinct chemical orthogona...
ORGANISM(S): Homo Sapiens 
2026-02-03 | PXD073964 |
ProteomicsModification localization and quality control for open database search results
Open (mass tolerant) search of tandem mass spectra shows great potential in the comprehensive detection of post-translational modifications in shotgun proteomics. However, this search strategy has not been widely used by the community, and one bottleneck of it is the lack of appropriate algorithms f...
ORGANISM(S): Homo Sapiens 
2019-01-17 | PXD012394 |
ProteomicsNoninvasive urinary protein signatures combined clinical information associated with Microvascular Invasion Risk in patients with HCC
Microvascular invasion (MVI) is the main factor affecting the prognosis of patients with hepatocellular carcinoma (HCC). There is an urgent need for reliable preoperative prediction of MVI indicators in order to formulate a reasonable treatment plan for patients.
ORGANISM(S): Homo Sapiens 
2022-10-13 | PXD037409 |
ProteomicsInvestigating the Therapeutic Impact of Traditional Chinese Medicine on Asthma through Proteomic Sequencing of Mouse Lung Tissue
Construct asthma mouse models using OVA and CFA, intervene with Warming Yang and Nourishing Kidney Approach and Xiao Qinglong Decoction respectively, and perform proteomic sequencing on the lung tissues of mice from control group-1, model group-1 and warming yang and tonifying kidney therapy group, ...
ORGANISM(S): Mus Musculus 小家鼠 
2024-11-15 | PXD058120 |
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