Proteomics

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Noninvasive urinary protein signatures combined clinical information associated with Microvascular Invasion Risk in patients with HCC


ABSTRACT: Microvascular invasion (MVI) is the main factor affecting the prognosis of patients with hepatocellular carcinoma (HCC). There is an urgent need for reliable preoperative prediction of MVI indicators in order to formulate a reasonable treatment plan for patients.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wantao Ying  

PROVIDER: PXD037409 | iProX | Thu Oct 13 00:00:00 BST 2022

REPOSITORIES: iProX

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Noninvasive urinary protein signatures combined clinical information associated with microvascular invasion risk in HCC patients.

Wang Yaru Y   Meng Bo B   Wang Xijun X   Wu Anke A   Li Xiaoyu X   Qian Xiaohong X   Wu Jianxiong J   Ying Wantao W   Xiao Ting T   Rong Weiqi W  

BMC medicine 20231205 1


<h4>Background</h4>Microvascular invasion (MVI) is the main factor affecting the prognosis of patients with hepatocellular carcinoma (HCC). The aim of this study was to identify accurate diagnostic biomarkers from urinary protein signatures for preoperative prediction.<h4>Methods</h4>We conducted label-free quantitative proteomic studies on urine samples of 91 HCC patients and 22 healthy controls. We identified candidate biomarkers capable of predicting MVI status and combined them with patient  ...[more]

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