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100 μg of the peptide mixture of each sample was labeled using TMT reagent, according to the manufacturer’s instructions (Thermo Fisher Scientific). The marked mixed peptide segments were graded using the Agilent 1260 Infinity II HPLC system, and each sample was separated using the EASY-nLC system. ...
ORGANISM(S): Rattus Norvegicus 
2024-04-28 | PXD051807 |
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
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