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The alteration of metabolism is essential for the initiation and progression of numerous types of cancer, including colorectal cancer (CRC). Metabolomics has been used to study CRC. At present, the reprogramming of the metabolism in CRC remains to be fully elucidated. In the present study, comprehen...
2024-02-08 | MTBLS8090 | MetaboLights
We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of L...
ORGANISM(S): Homo sapiens 
The experimental results revealed 2727 phosphorylated proteins, 5258 phosphorylated peptides and 5096 phosphorylation sites, which included 5252 quantifiable phosphorylated peptides and 5091 quantifiable phosphorylation sites on 2725 quantifiable modified proteins
ORGANISM(S): Lycium Barbarum 
2024-12-10 | PXD058720 |
The AF4/FMR2 proteins AFF1 and AFF4 act as a scaffold to assemble the Super Elongation Complex (SEC) that strongly activates transcriptional elongation of HIV-1 and cellular genes. Although they can dimerize, it is unclear whether the dimers exist and function within a SEC in vivo. Furthermore, it i...
ORGANISM(S): Homo sapiens 
We sought to identify the potential specific roles of the MTOR signalling in cumulus cells by comparing the transcriptomes of the Control (treated with the DMSO vehicle) and MTOR-specific inhibitor Torin 1(5uM)-treated cumulus-oocyte complexes that were cultured for 16 hours. We compared the transcr...
ORGANISM(S): Mus musculus 
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