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UnknownThe long-term effect of acupuncture for patients with chronic tension-type headache: study protocol for a randomized controlled trial.
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S-EPMC5627426 | biostudies-literature
TranscriptomicsThe DNA methylation landscape of human early embryos
Our data provided a genome-wide DNA methylation landscape of human early development embryos, including human MII oocytes, sperm, zygotes, 2-cell to 8-cell embryos, morula, blastocyst and postimplantation embryos at single base resolution. In total, 44 samples including biological and technical repl...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-49828 | biostudies-arrayexpress
GenomicsWhole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
5-Hydroxymethylcytosine (hmC) is particularly abundant in mammalian brains with yetto be revealed functions. Here, we present genome-wide and single-base-resolutionmaps of hmC and mC in the human brain. We demonstrated that hmCs increasemarkedly from the fetal to the adult stage, and in the adult br...
ORGANISM(S): Homo sapiens 
2014-02-22 | E-GEOD-55249 | biostudies-arrayexpress
MetabolomicsMulti-omic Profiling of Multi-Biosamples Reveals the Role of Amino Acid and Nucleotide Metabolism in Endometrial Cancer
Endometrial cancer (EC) is one of the most common gynecological cancers. Finding biomarkers of EC can support its diagnosis in a non- or minimally-invasive way. In this work, we integrated metabolomics and proteomics for the analysis of multiple types of biosamples to gain a more comprehensive view ...
2022-03-28 | MTBLS3935 | MetaboLights
ProteomicsMulti-omic Profiling of Multi-Biosamples Reveals the Role of Amino Acid and Nucleotide Metabolism in Endometrial Cancer
This dataset is part of the multi-omic profiling of endometrial cancer. 12 EC and 11 controls were subjected to untargeted proteomic analysis, using a nano-UHPLC-Orbitrap-MS/MS system in the positive ion mode. A total of 9042 proteins were identified and quantified combining the EC and control group...
ORGANISM(S): Homo Sapiens 
2022-03-28 | PXD030222 |
GenomicsEpigenomic landscape during organ formation in human early embryos
Here we present the whole genome ChIP-Seq analyses of a wide variety of histone marks, H3K27ac, H3K4me1, H3K4me3, and H3K27me3 in the brain, heart, and liver, along with the RNA-seq data of these organs of early human embryos 12 weeks after gestation. In total, brain, heart, and liver of early human...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-63634 | biostudies-arrayexpress
MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
ProteomicsThe comprehensive stage-specific proteome across human pre-implantation embryo development at single-cell level
Although the landscape of epigenomic and transcriptomic regulation during human pre-implantation development has been depicted by applying single-cell sequencing, the investigation of embryonic proteome is almost unrevealed due to the insufficient input quantity from precious human embryonic samples...
ORGANISM(S): Homo Sapiens 
2021-04-20 | PXD024267 |
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