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ProteomicsInvestigation of the aging process of C. elegans using integrated quantitative proteomics and N-glycoproteomics
N-glycosylation, a highly diverse and abundant post-translational modification, critically regulates organismal aging. Leveraging the Caenorhabditis elegans (C. elegans) model, which exhibits distinctive N-glycosylation features including highly fucosylated core structures, bisecting β1,4-galactose,...
ORGANISM(S): Caenorhabditis elegans 
2026-09-14 | PXD067150 | Pride
Aging process Nanolc-esi-ms/ms N-glycosylation Caenorhabditis elegans 
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
ProteomicsA comprehensive landscape of human organ N-glycoproteome
N-glycosylation, as a common post-translational modification with enormous structures, plays key roles in protein folding, cellular recognition and signaling pathways. State-of-the-art mass spectrometry-based N-glycoproteomics has enabled deep N-glycoproteome characterization of various human organs...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD070547 | Pride
Tissue Human N-glycosylation Profile 
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
Proteomicscomparative proteomics studies of the wild strain SC1401 and the tfoX deficient strain
Natural transformation, as one of the horizontal gene transfer (HGT) modes of bacteria, allows bacteria to actively uptake foreign DNA under natural conditions and integrate it into their genome through homologous recombination. Natural transformation plays an vital role in the rapid spread of patho...
ORGANISM(S): Glaesserella Parasuis 
2022-03-17 | PXD032382 |
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