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Comparative proteomics studies of the wild strain SC1401 and the tfoX deficient strain

ABSTRACT: Natural transformation, as one of the horizontal gene transfer (HGT) modes of bacteria, allows bacteria to actively uptake foreign DNA under natural conditions and integrate it into their genome through homologous recombination. Natural transformation plays an vital role in the rapid spread of pathogen virulence factors and resistance genes, resulting in the emergence of multidrug resistant or highly pathogenic strains.To investigate the mechanism by which tfoX regulates the natural transformation process of Glaesserella parasuis, comparative proteomics studies were performed on the parent wild strain SC1401 and the tfoX deficient strain.

ORGANISM(S): Glaesserella Parasuis

SUBMITTER: Yiping Wen

PROVIDER: PXD032382 | iProX | Thu Mar 17 00:00:00 GMT 2022

REPOSITORIES: iProX

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The molecular diversity of transcriptional factor TfoX is a determinant in natural transformation in Glaesserella parasuis.

Tang Xiaoyu X Yang Zhen Z Dai Ke K Liu Geyan G Chang Yung-Fu YF Tang Xinwei X Wang Kang K Zhang Yiwen Y Hu Bangdi B Cao Sanjie S Huang Xiaobo X Yan Qigui Q Wu Rui R Zhao Qin Q Du Senyan S Lang Yifei Y Han Xinfeng X Huang Yong Y Wen Xintian X Wen Yiping Y

Frontiers in microbiology 20220729

Natural transformation is a mechanism by which a particular bacterial species takes up foreign DNA and integrates it into its genome. The swine pathogen Glaesserella parasuis (G. parasuis) is a naturally transformable bacterium. The regulation of competence, however, is not fully understood. In this study, the natural transformability of 99 strains was investigated. Only 44% of the strains were transformable under laboratory conditions. Through a high-resolution melting curve and p ...[more]

PMID: 35966685

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