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MetabolomicsTubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis

Profibrotic proximal tubular (PT) were identified as a unique phenotype of PTCs in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT sub...

2024-05-28 | MTBLS9985 | MetaboLights
ProteomicsLong noncoding RNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5
Cisplatin resistance is a major therapeutic challenge in advanced head and neck squamous cell carcinoma (HNSCC). Here, we aimed to investigate the key signaling pathway for cisplatin resistance in HNSCC cells. HNSCC cell lines that were sensitive (HN4 and HN30) or resistant (HN4/DDP and HN30/DDP) to...
ORGANISM(S): Homo Sapiens 
2020-11-28 | PXD022799 |
ProteomicsProteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium Wilfordii multiglycoside in mice
Tripterygium wilfordii multiglycoside (GTW), extracted and purified from the peeled roots of Tripterygium wilfordii Hook.f. (TwHF), is a well-known traditional Chinese medicine and applied to various autoimmune diseases clinically. However, it has been reported to cause severe liver injury. At prese...
ORGANISM(S): Mus Musculus 
2022-11-10 | PXD038084 |
ProteomicsHSGA glioma tissue and benign tissue in Huashan Hospital
HSGA glioma tissue and benign tissue in Huashan Hospital
ORGANISM(S): Homo Sapiens 
2024-09-27 | PXD056311 |
ProteomicsBCAA insufficiencies lead to premature ovarian insufficiency via ceramide induced elevation of ROS
Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle-stimulating hormone (FSH). Though POI affects many aspects of women’s health, its major causes remain unknown. Many clinical studies have shown that POI pati...
ORGANISM(S): Homo Sapiens 
2022-10-13 | PXD037353 |
ProteomicsIntegrative Proteogenomic Characterization Reveals Therapeutic Targets in Poorly Differentiated and Anaplastic Thyroid Cancers
In our study, we constructed a multicenter thyroid-cancer cohort consisting of 467 formalin-fixed paraffin-embedded (FFPE) samples, among which WES, proteome, and phosphorylated proteome analysis were conducted. Thyroid tumors consisted of 124 ATC samples, 47 PDTC samples and 177 PTC samples (includ...
ORGANISM(S): Homo Sapiens 
2025-03-16 | PXD054521 |
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