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ProteomicsLARGE2 mediates O-glycosylation in HT-29 colorectal cancer cells
The O-glycosyltransferase LARGE2 attaches a laminin-binding matriglycan structure on alpha-Dystroglycan (α-DG) to mediate the interaction of different cell types with their laminin-containing basement membrane. We used HT-29 CRC cells, characterized by low endogenous LARGE2 gene expression, to ectop...
ORGANISM(S): Homo sapiens (Human) 
2020-06-28 | PXD013800 | Pride
Human O-glycosylation Colorectal cancer 
ProteomicsTcell surface analysis - A combined omics approach to generate the surface atlas of human naive CD4+ T cells during early TCR activation
Naive CD4+ T cells are the common precursors of multiple effector and memory T cell subsets and possess a high plasticity in terms of differentiation potential. This stem-cell like character is important for cell therapies aiming at regeneration of specific immunity. Cell surface proteins are crucia...
ORGANISM(S): Homo sapiens (Human) 
2015-05-27 | PXD001432 | Pride
T-cells 
OtherA combined omics approach to generate the surface atlas of human naive CD4+ T cells during early TCR activation.
Data from ProteomeXchange, PXD ID: PXD001432. File: SUK5557A8MA2__008-Spender2_3hP SUK5557A8MA2-40-215297.mzml. Published as part of . From the Abstract: {{i}} ... Periodate oxidation and aniline-catalyzed oxime ligation (PAL) technology was applied with subsequent quantitative LC-MS/MS (PAL-qLC-MS...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310020145 | GPMDB
Resource Reanalysis 
Proteomicsγ-glutamylcysteine (GGC) supplementation and p-LPS challenge causes distinct proteomic changes to primary airway epithelial cell models of Cystic Fibrosis
Cystic fibrosis (CF) is a life limiting inherited condition associated with recurrent bacterial infections, inflammation, oxidative stress and loss of lung function. CF is characterised by deficiencies in both intra- and extracellular glutathione (GSH) levels. This GSH depletion is exacerbated by ba...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019084 | Pride
Lps Glutathione Cystic fibrosis Airway epithelial cells Qlc-ms/ms Γ-glutamylcysteine Oxidative stress 
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