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TranscriptomicsMolecular Rejuvenation of Gene Expression Pattern of Photoaged and Intrinsically Aged Human Skin by Broadband Light Treatment
Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply deep sequencing of RNA 3' ends ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin ...
ORGANISM(S): Homo sapiens 
2012-07-30 | E-GEOD-39170 | biostudies-arrayexpress
UnknownPolymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients.
Not available
S-EPMC4394094 | biostudies-literature
GenomicsGenomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions.
Long intergenic noncoding RNAs (lincRNAs) are key regulators of chromatin state, yet the nature and sites of RNA-chromatin interaction are mostly unknown. Here we introduce Chromatin Isolation by RNA Purification (ChIRP), where tiling oligonucleotides retrieve specific lincRNAs and bound protein and...
ORGANISM(S): Drosophila 
2011-09-29 | E-GEOD-31332 | biostudies-arrayexpress
GenomicsA pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics
Pseudogenes are thought to be inactive gene sequences, but recent evidence of extensive pseudogene transcription raised the question of potential function. Here we discover and characterize the sets of lncRNAs induced by inflammatory signaling via TNFα. TNFα regulates hundreds of lncRNAs, including...
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-47494 | biostudies-arrayexpress
TranscriptomicsBRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10
BRMS1L (breast cancer metastasis suppressor 1 likeM-oM-
ORGANISM(S): Homo sapiens 
2014-09-12 | E-GEOD-61354 | biostudies-arrayexpress
TranscriptomicsEssential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency
Here we delineate the roles of RNA binding for WDR5 function on chromatin state and murine embryonic stem cell (ESC) maintenance. Examination of global transcriptional changes and mapping genome-wide transcription factors occupancy at distinct time points during the transdifferentiation process
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-53035 | biostudies-arrayexpress
TranscriptomicsDynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging- Related Transcriptional Networks
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-28641 | biostudies-arrayexpress
UnknownA combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch.
Not available
S-EPMC9772573 | biostudies-literature
UnknownGender differences in the association between the uric acid to high-density lipoprotein cholesterol ratio and diabetes risk: a mediation analysis of c-reactive protein, triglycerides, and insulin resistance.
Not available
S-EPMC11654205 | biostudies-literature
UnknownVitamin C alleviates aging defects in a stem cell model for Werner syndrome.
Not available
S-EPMC4930768 | biostudies-literature
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