We selected 24 formalin-fixed paraffin-embedded tissue blocks from 6 patients with primary liver cancer (PLC) and who underwent surgical resection at Eastern Hepatobiliary Surgery Hospital (EHBH) for proteomics analysis,
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
