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MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
ProteomicsProteomics reveals the mechanism of Qingre Huo xue decoction in treating rheumatoid arthritis
Rheumatoid arthritis is an autoimmune disease characterized by chronic synovitis, which can lead to irreversible joint damage as well as cardiovascular and respiratory system damage. The Qingre Huoxue Decoction is a Chinese medicine compound that has been clinically proven to be effective in treatin...
ORGANISM(S): Homo Sapiens 
2024-07-23 | PXD054129 |
TranscriptomicsRNA-seq analysis reveals the role of red light in resistance against Pseudomonas syringae pv. tomato DC3000 in tomato plants
Background: Plants attenuate their responses to a variety of bacterial and fungal pathogens, leading to higher incidences of pathogen infection at night. However, little is known about the molecular mechanism responsible for the light-induced defence response; transcriptome data would likely facilit...
ORGANISM(S): Solanum lycopersicum 
2015-09-14 | E-GEOD-64087 | biostudies-arrayexpress
ProteomicsHSPA1A and DNAJB1 regulate NELF condensate reversibility to safeguard transcriptional recovery under heat stress
The negative elongation factor (NELF) is essential in establishing RNA Polymerase II (Pol II) pausing at promoter-proximal regions, providing a key regulatory checkpoint for precise gene expression control. In response to heat shock (HS) stress, NELF has been observed to form nuclear condensates, bu...
ORGANISM(S): Homo Sapiens 
2025-05-21 | PXD064175 |
ProteomicsPulmonary and Renal Long COVID at Two-year Revisit
To outline the temporal changes of long COVID, we profiled serum proteomes (dataset SP2) and urine proteomes (dataset UP2). The SP2 were measured for 37 patients during the disease (T1), the convalescence (T2), and at the 1-year revisit (T3); the UP2 were measured for 28 patients during the disease ...
ORGANISM(S): Homo Sapiens 
2024-06-04 | PXD027557 |
UnknownThe landscape of tolerated genetic variation in humans and primates.
Not available
S-EPMC10187174 | biostudies-literature
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