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TranscriptomicsChIP analysis on a custom tiling array of U251 human glioblastoma cell line
Missense mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines. In contrast to wild-type p53, the mutant p53 (mutp53) protein has lost the transcriptional activity towards pro-apoptotic and growth arrest genes, but retained the property to interact with DNA...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-35453 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of mouse embryonic stem cells in response to changes in Sall4
Sall4 is a stem cell factor which is important for embryogenesis. We have genetically modified Sall4 in mouse embryonic stem cells to access the transcriptional changes. There are three different genetic modifications for the ES cells in the form of Sall4 Knockout (KO), Sall4 Zinc Finger Cluster 4 M...
ORGANISM(S): Mus musculus 
2021-01-05 | E-MTAB-7343 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of U251 human glioblastoma cell line
The human TP53 gene is frequently mutated in tumors and cell lines. Unlike other tumor suppressors that are commonly inactivated by deletions or nonsense mutations, the majority of p53-mutations are missense point mutations that result in the expression of a full-length protein with an altered amino...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-35454 | biostudies-arrayexpress
TranscriptomicsGene expression and ChIP-chip analysis of U251 human glioblastoma cell line
Using human U251 glioblastoma cells with endogenous mutp53 expression as a model, we performed a ChIP-chip analysis of mutp53 binding sites on a custom tiling array, coupled with global expression profiling and an analysis of the epigenetic status of mutp53 regulated promoters. Mutp53 binds preferen...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-35500 | biostudies-arrayexpress
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