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TranscriptomicsSystemic inflammation is associated with differential gene expression and airway neutrophilia in asthma
Systemic inflammation is reported to be associated with neutrophilic airway inflammation in asthma, this study aimed to examine the molecular mechanisms of the neutrophilia that is associated with systemic inflammation, and hypothesized that asthma patients with systemic inflammation have a group of...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-43397 | biostudies-arrayexpress
TranscriptomicsA sputum gene expression signature of six biomarkers identifies asthma inflammatory phenotype and steroid responsiveness
This study identifies differentially expression genes in the sputum of people with eosinophilic, neutrophilic and paucigranulocytic asthma. A selection of markers identified using this microarray were further validated using qPCR on a wider sample set. Gene expression profiles were generated from in...
ORGANISM(S): Homo sapiens 
2014-03-25 | E-GEOD-45111 | biostudies-arrayexpress
ProteomicsOn the reproducibility of label-free quantitative cross-linking/mass spectrometry
Quantitative cross-linking/mass spectrometry (QCLMS) is an emerging approach to study conformational changes of proteins and multi-subunit complexes. Distinguishing protein conformations requires reproducibly identifying and quantifying cross-linked peptides. Here we analyzed the variation between m...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007250 | Pride
Cross-linking Mass-spectrometry Skyline Quatitation 
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