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TranscriptomicsIncrease in membrane cholesterol of neurons in culture recapitulates AlzheimerM-bM-^@M-^Ys disease early phenotypes.
Levels of membrane-associated cholesterol were shown to be increased in the brain of individuals with sporadic AlzheimerM-bM-^@M-^Ys disease (AD) and correlated with the severity of the disease. We previously found that heavy membrane cholesterol burden promotes amyloid precursor protein (APP) endoc...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-46221 | biostudies-arrayexpress
TranscriptomicsRoot transcriptome remodeling of Arabidopsis in response to high levels of magnesium sulfate
Martian regolith (unconsolidated surface material) is a potential medium for plant growth in bioregenerative life support systems during manned missions on Mars. However, hydrated magnesium sulfate mineral levels in the regolith of Mars can reach as high as 10 wt%, and would be expected to be highly...
ORGANISM(S): Arabidopsis thaliana 
2010-09-17 | E-GEOD-20109 | biostudies-arrayexpress
TranscriptomicsUnraveling the Specific Ischemic Core and Penumbra Transcriptome in Permanent Middle Cerebral Artery Occlusion Model Mice Brain Treated with Neuropeptide PACAP38
Our group has been systematically investigating effects of the neuropeptide pituitary adenylate-cyclase activating polypeptide (PACAP) on the ischemic brain. To do so, we have established and utilizing the permanent middle cerebral artery occlusion (PMCAO) mouse model, where PACAP38 (1 pmol) injecti...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-62884 | biostudies-arrayexpress
TranscriptomicsGenomic alterations during the progress of pulmonary hypertension
Pulmonary hypertension (PH), a rare disorder is a complication of a number of cardiopulmonary, unrelated systemic diseases, drug toxicity and genetic mutations. Major advances have been made in the field, but the pathogenesis of PH is not yet understood. Several experimental models such as monocro...
ORGANISM(S): Rattus norvegicus 
2015-09-04 | E-GEOD-72707 | biostudies-arrayexpress
TranscriptomicsPulmonary retention of titanium dioxide nanoparticles and biological outcomes following low dose instillation in mice
Pulmonary exposure to high doses of nanoparticles (NP) leads to well characterized lung toxicity in addition to long-term NP retention. However, pulmonary NP accumulation and toxicity following low dose exposures are not well described. In the present study we sought to: (1) investigate particle ret...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-41041 | biostudies-arrayexpress
TranscriptomicsTranscriptomic responses of juvenile Pacific whiteleg shrimp, Litopenaeus vannamei, to hypoxia and hypercapnic hypoxia
Here we used microarrays to characterize changes in global gene expression in the hepatopancreas of Pacific white shrimp, Litopenaeus vannamei, exposed to short term (4 h) hypoxia (H) or hypercapnic hypoxia (HH) or long term (24 h) H or HH, compared to animals in air-saturated water (normoxia). Th...
ORGANISM(S): Litopenaeus vannamei 
2012-04-29 | E-GEOD-29029 | biostudies-arrayexpress
TranscriptomicsVimentin DNA Methylation Predicts Survival in Breast Cancer
Purpose:The Vimentin gene plays a pivotal role in epithelial-to-mesenchymal transition (EMT) and is known to be over-expressed in the prognostically poor basal-like breast cancer subtype. Recent studies have reported Vimentin DNA methylation in association with poor clinical outcomes in other solid ...
ORGANISM(S): Homo sapiens 
2013-02-19 | E-GEOD-35629 | biostudies-arrayexpress
TranscriptomicsGlobal Expression of Molecular Transporters in the Human Vaginal Tract
Pre-exposure chemoprophylaxis using antiretroviral agents is a promising strategy for the prevention of sexual HIV transmission in women. Molecular transporters in the human vaginal tract may play a pivotal role in determining drug disposition and, consequently, pharmacodynamic outcomes in these eff...
ORGANISM(S): Homo sapiens 
2014-01-29 | E-GEOD-49892 | biostudies-arrayexpress
TranscriptomicsMicro-scale genomic copy number aberrations as another means of mutagenesis in breast cancer
Introduction: In breast cancers, the basal-like subtype has high levels of genomic instability relative to other breast cancer subtypes with many basal-like-specific regions of aberration. There is evidence that this genomic instability extends to smaller scale genomic aberrations as well, as shown ...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-36889 | biostudies-arrayexpress
TranscriptomicsGenomics of Estradiol-3-Sulfate Action in the Ovine Fetal Hypothalamus
In the fetal sheep during late gestation sulfoconjugated estrogens in plasma reach a concentration 40-100 times greater than unconjugated estrogens. The objective of the present study was to determine the genomics of estradiol-3-sulfate (E2S) action in the fetal brain. The hypothesis was that E2S st...
ORGANISM(S): Ovis aries 
2011-08-02 | E-GEOD-31184 | biostudies-arrayexpress
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