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TranscriptomicspsiCLIP of SmB, Prp16 and Prp22 in C, C* and P spliceosomal complexes
Despite the major progress made into spliceosome mechanisms through CryoEM, a major obstacle of this approach is its inability to map the positioning of helicases on the RNA substrate. Here we present a method ‘psiCLIP’ which probes protein-RNA interactions in specific spliceosomal states. The metho...
ORGANISM(S): Saccharomyces cerevisiae 
2020-03-15 | E-MTAB-8895 | biostudies-arrayexpress
UnknownPharmacokinetics of asciminib in the presence of CYP3A or P-gp inhibitors, CYP3A inducers, and acid-reducing agents.
Not available
S-EPMC9283742 | biostudies-literature
UnknownSTRling: a k-mer counting approach that detects short tandem repeat expansions at known and novel loci.
Not available
S-EPMC9753380 | biostudies-literature
GenomicsGenome-wide binding profiles of an artificial zinc finger protein with or without a KLF3 functional domain
Transcription factors are often regarded as having two distinct components: a DNA binding domain (DBD) to allow binding to the regulatory region of a target gene and a trans-acting functional domain (FD) to modulate gene expression. Recently, it is becoming clear that the DBDs of transcription facto...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-69739 | biostudies-arrayexpress
GenomicsWhole Exome Sequencing of Chronic Lymphocytic Leukemia

The somatic genetic basis of chronic lymphocytic leukemia (CLL), a common and clinically heterogenous adult leukemia, remains poorly understood. Massively parallel sequencing technology now provides a method for systematic discovery of genetic alterations that underlie disease, and for uncovering...

phs000435.v1.p1 | EGA
UnknownEpistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice.
Not available
S-EPMC10942616 | biostudies-literature
TranscriptomicsThe genomic architecture of sickle cell disease in children from West Africa
Sickle cell disease (SCD) is caused by a pathogenic hemoglobin (Hb) mutation, yet patients can have dramatically variable clinical manifestations. Here we address the genetic basis of this clinical heterogeneity. Using a systems genetics approach, we performed whole blood gene expression analysis an...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-35007 | biostudies-arrayexpress
UnknownLow Serum Insulin-like Growth Factor-I Is Associated with Decline in Hippocampal Volume in Stable Mild Cognitive Impairment but not in Alzheimer's Disease.
Not available
S-EPMC9484094 | biostudies-literature
TranscriptomicsWhole-genome gene expression profiles of non-tumorous human lung tissues: UBC set
We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD). The samples from the University of British Columbia ...
ORGANISM(S): Homo sapiens 
2012-06-10 | E-GEOD-23529 | biostudies-arrayexpress
UnknownA computerized order entry system was adopted with high user satisfaction at an orthopedic teaching hospital.
Not available
S-EPMC3903951 | biostudies-literature
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