Sort   by:  
 Page size 
UnknownClosed Genome and Comparative Phylogenetic Analysis of the Clinical Multidrug Resistant Shigella sonnei Strain 866.
Shigella sonnei is responsible for the majority of shigellosis infections in the US with over 500,000 cases reported annually. Here, we present the complete genome of the clinical multidrug resistant (MDR) strain 866, which is highly susceptible to bacteriophage infections. The strain has a circular...
S-EPMC6128377 | biostudies-literature
UnknownLongitudinal Growth Outcomes Following First-line Treatment for Pediatric Patients With Eosinophilic Esophagitis.

Objectives

No formal comparative effectiveness studies have been conducted to evaluate the effect of eosinophilic esophagitis (EoE) treatment choice on long-term growth in pediatric patients. Long-term studies of inhaled corticoid steroids in asthma, however, suggest possible effects on line...
S-EPMC6449848 | biostudies-literature
UnknownHigh- and low-dose oral delayed-release mesalamine in children with mild-to-moderately active ulcerative colitis.

Objective

The aim of the study was to assess the safety and efficacy of high- and low-dose oral, delayed-release mesalamine in a randomized, double-blind, active control study of children with mild-to-moderately active ulcerative colitis.

Methods

Patients ages 5 to 17 years, with a Pe...
S-EPMC4255757 | biostudies-literature
UnknownFine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein.

Objectives

To perform fine mapping of the autoimmunity susceptibility gene BLK and identify functional variants involved in systemic lupus erythematosus (SLE).

Methods

Genotyping of 1163 European SLE patients and 1482 controls and imputation were performed covering the BLK gene with 1...
S-EPMC3375585 | biostudies-literature
UnknownLow Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies.

Background

Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also a...
S-EPMC6195673 | biostudies-literature
UnknownNovel risk loci for COVID-19 hospitalization among admixed American populations.
The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in t...
S-EPMC11449485 | biostudies-literature
UnknownAssociation of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study.

Background

Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families represent the tip of the iceberg of a subset of COVID-19...
S-EPMC7987337 | biostudies-literature
UnknownSpatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions.
Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41-6.57%) across Spain. Our aim was to estimate the levels of regional clustering for ...
S-EPMC6421502 | biostudies-literature
UnknownCondition-Specific Growth Charts for Children With Alagille Syndrome.

Importance

Different degrees of growth delay have been reported in children with Alagille syndrome (ALGS), yet these patients are routinely evaluated using standard growth charts.

Objective

To develop condition-specific growth charts for ALGS using modern statistical approaches.

De...

S-EPMC12645329 | biostudies-literature
UnknownLow-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of ...
S-EPMC4311266 | biostudies-literature
Sort   by:  
 Page size