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GenomicsThe SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts
PRJNA646901 | ENA
ProteomicsNAT10-dependent N4-acetylcytidine (ac4C) reprograms R-loops and promotes cancer stem cell growth
R-loop remodeling dynamically regulates chromatin states and gene expression; however, its exploitation by cancer to sustain self-renewal and malignancy remains poorly understood. Here, we found that glioblastoma (GBM) stem cells (GSCs) display highly active R-loops compared to differentiated tumor ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-10 | PXD077002 | Pride
Ac4c Cancer stem cell Nat10 Glioblastoma R-loop remodeling Glioblastoma stem cell 
OtherThe SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts
ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved multi-subunit chromatin remodelers (cBAF, ncBAF and PBAF) that share the BRG1 (also known as SMARCA4) subunit responsible for the main ATPase activity. BRG1 is the most frequ...
ORGANISM(S): Homo sapiens 
2021-05-10 | GSE154631 | GEO
ProteomicsDifferent SWI/SNF complexes coordinately promote R-loop- and RAD52- dependent transcription-coupled homologous recombination
The SWI/SNF family of ATP-dependent chromatin remodeling complexes are implicated in multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF and PBAF complexes are two major types of SWI/SNF complexes that are functionally distinguished by their exclusive subunits. Accumula...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD035140 | Pride
Swi/snf  transcription-coupled homologous recombination  r-loops  rad52  dna damage response  arid1a  arid1b  brg1  brm 
GenomicsHIRA protects telomeres against R-loop-induced instability in ALT cancer cells [CUT&RUN]
HIRA protects telomeres against R-loop-induced instability in ALT cancer cells [CUT&RUN]
PRJNA1120849 | ENA
GenomicsHIRA protects telomeres against R-loop-induced instability in ALT cancer cells [ATAC-seq]
HIRA protects telomeres against R-loop-induced instability in ALT cancer cells [ATAC-seq]
PRJNA1120891 | ENA
UnknownARID1A regulates R-loop associated DNA replication stress.
Not available
S-EPMC8055027 | biostudies-literature
GenomicsHIRA protects telomeres against R-loop-induced instability in ALT cancer cells [ATAC-seq]
Alterations to chromatin modifiers, such as the inactivating mutations in the ATRX-DAXX chromatin remodeling/histone H3.3 deposition complex, are implicated as drivers of the cancer-specific Alternative Lengthening of Telomeres (ALT) pathway. Prior studies revealed that HIRA adapts to compensate for...
ORGANISM(S): Homo sapiens 
2024-10-21 | GSE269268 | GEO
GenomicsHIRA protects telomeres against R-loop-induced instability in ALT cancer cells [CUT&RUN]
Alterations to chromatin modifiers, such as the inactivating mutations in the ATRX-DAXX chromatin remodeling/histone H3.3 deposition complex, are implicated as drivers of the cancer-specific Alternative Lengthening of Telomeres (ALT) pathway. Prior studies revealed that HIRA adapts to compensate for...
ORGANISM(S): Homo sapiens 
2024-10-21 | GSE269261 | GEO
UnknownHIRA protects telomeres against R-loop-induced instability in ALT cancer cells.
Not available
S-EPMC11698518 | biostudies-literature
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