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MetabolomicsThe effect of an NAT10 inhibitor (remodelin) on inflammation-related genes in the treatment of thalamic hemorrhage based on metabolic data

Thalamic hemorrhage is a disease caused by hemorrhage of the thalamic brain parenchyma and is accompanied by an inflammatory response during development. NAT10 has been associated with a wide range of diseases. The aim of this study was to explore the molecular mechanisms associated with the use ...

2025-11-13 | MTBLS11941 | MetaboLights
MetabolomicsAdipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation

Multiple myeloma (MM) remains an incurable hematologic malignancy despite advances in treatment. While obesity is a well-established risk factor, the underlying metabolic mechanisms by which adipocytes contribute to disease progression remain elusive. Here, we uncover a critical m...

2026-05-07 | MTBLS14445 | MetaboLights
MetabolomicsDeciphering the Role of N-Acetyltransferase 10 in Thalamic Hemorrhage Through Integrative Multi-Omics and Experimental Validation

Thalamic hemorrhage (TH) is a severe neurological condition, the molecular mechanisms of which are poorly understood, particularly in clinical settings. N-acetyltransferase 10 (NAT10), a regulator of RNA N4-acetylcytidine (ac4C) modification, has been implicated in cell cycle regulation and ident...

2025-11-18 | MTBLS11752 | MetaboLights
TranscriptomicsNAT10 inhibition improves cellular phenotypes of Hutchinson-Gilford progeria syndrome by restoring the Transportin-1 pathway
In this experiment, we aim to examine the role of NAT10 inhibition in Hutchinson-Gilford progeria syndrome (HGPS), a rare but devastating premature ageing syndrome caused by a mutation in the LMNA gene. NAT10 inhibition improves HGPS cellular phenotypes by releasing Transportin-1 (TNPO1) from the cy...
ORGANISM(S): Homo sapiens 
2018-06-25 | E-MTAB-6651 | biostudies-arrayexpress
ProteomicsDIA quantitative protein mass spectrometry of RBE cells knockout NAT10
To further explore the role of NAT10 in ICC, we constructed stable NAT10-knockdown RBE cells using shRNA and performed DIA quantitative proteomic analysis to explore its influence on downstream protein fuction.
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD058708 | Pride
Intrahepatic cholangiocarcinoma nat10 dia 
TranscriptomicsTargeting NAT10 enhances healthspan and lifespan in a mouse model of human accelerated aging syndrome.
Targeting NAT10 enhances healthspan and lifespan in a mouse model of human accelerated aging syndrome.
ORGANISM(S): Mus musculus 
2018-03-22 | E-MTAB-6578 | biostudies-arrayexpress
ProteomicsIdentification of Khib substrates of histone regulated by NAT10
Having established NAT10’s regulatory role in lysine 2-hydroxyisobutyrylation, we aimed to identify the histone Khib sites targetedby NAT10. To this end, we extracted and digested core histones from cells with or without NAT10 depletion, followed by chemical derivatization of amine groups. The resul...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD066039 | Pride
Human liver cancer histone hplc-ms/ms 
ProteomicsNAT10-mediated ac4C-modification exacerbates ferroptosis by stabilizing HMOX1 in Deep vein thrombosis
In our study, we aimed to identify the pathways and genes closely related to DVT. Through proteomic analysis, we found that the ferroptosis signaling pathway showed differential expression, and we also discovered that NAT10 (a key acetyltransferase modified by ac4C) was significantly overexpressed i...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-26 | PXD067933 | Pride
Deep venous thrombosis  nat10  ac4c  hmox1  ferroptosis 
ProteomicsLactylation of NAT10 promotes N4‐acetylcytidine modification on tRNASer-CGA-1-1 to boost oncogenic DNA virus KSHV reactivation
N4-acetylcytidine (ac4C), a conserved but recently rediscovered RNA modification on tRNAs, rRNAs and mRNAs, is catalyzed by N-acetyltransferase 10 (NAT10). Lysine acylation is a ubiquitous protein modification that controls protein functions. Our latest study demonstrates a NAT10-dependent ac4C modi...
ORGANISM(S): Homo Sapiens 
PXD049447 |
GenomicsmRNA-seq in Control, NAT10 KD, NAT10 and Xrp1 KD in Drosophila
mRNA-seq in Control, NAT10 KD, NAT10 and Xrp1 KD in Drosophila
PRJNA1272413 | ENA
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