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GenomicsR-loop landscapes in yeast meiosis
R-loop landscapes in yeast meiosis
PRJNA705491 | ENA
GenomicsTDRD3 promotes DHX9 chromatin recruitment and R-loop resolution
TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution
PRJNA741480 | ENA
GenomicsRNA transcripts regulate G-quadruplex landscapes through G-loop formation (G4 and R-loop CUT&Tag)
RNA transcripts regulate G-quadruplex landscapes through G-loop formation (G4 and R-loop CUT&Tag)
PRJNA1120075 | ENA
TranscriptomicsMRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts
Rad50 is a component of the conserved MRE11-RAD50-NBS1 (MRN) complex, which functions in genome stability and the cell’s ability to deal with stalled DNA replication forks. We identified Rad50 as a factor important for R-loop tolerance and thus mapped DNA:RNA hybrids in Rad50KO cells and compare the...
ORGANISM(S): Saccharomyces cerevisiae 
2019-10-31 | E-MTAB-7885 | biostudies-arrayexpress
ProteomicsThe CGG triplet repeat binding protein 1 counteracts DNA secondary structure formation to prevent transcription-replication stress
Short tracts of trinucleotide repeats with less than 10 repeats are found frequently throughout the genome without any apparent negative impact on DNA replication fork progression or transcription elongation. CGG binding protein 1 (CGGBP1) binds to CGG triplet repeats and has been implicated in mult...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD045654 | Pride
Transcription-replication conflicts Genomic instability Cggbp1 R-loop structure Cgg-trinucleotide repeats Replication stress Transcription regulation Dna damag G-quadruplex structure 
TranscriptomicsGenome-wide Map of R-loop Reveals its interplays with Transcription and Genome Integrity during Germ Cell Meiosis
R-loop is a three-strand nucleic acid structure composed of mRNA and DNA. In mammalian meiotic cells, R-loop mainly distributed at promoter-related regions, and combined with systematically transcriptome analysis showed R-loop was closely related to transcription in meiotic process. Moreover, knocko...
ORGANISM(S): Mus musculus 
2023-09-21 | GSE190430 | GEO
GenomicsGenome-wide Map of R-loop Reveals its interplays with Transcription and Genome Integrity during Germ Cell Meiosis
Genome-wide Map of R-loop Reveals its interplays with Transcription and Genome Integrity during Germ Cell Meiosis
PRJNA787109 | ENA
TranscriptomicsTDRD3 promotes DHX9 chromatin recruitment and R-loop resolution
R-loops, which consist of a DNA/RNA hybrid and a displaced single-stranded DNA (ssDNA), are increasingly recognized as critical regulators of chromatin biology. R-loops are particularly enriched at gene promoters, where they play important roles in regulating gene expression. However, the molecular ...
ORGANISM(S): Homo sapiens 
2021-06-26 | GSE178905 | GEO
OtherR-loop landscapes in yeast meiosis
Meiotic recombination is initiated by the Spo11-dependent programmed DNA double-strand breaks (DSBs) that are preferentially concentrated within genomic regions known as hotspots, but the factor(s) which specify the positions for meiotic DSB hotspots remain unclear. Here, we show that the frequency ...
ORGANISM(S): Saccharomyces cerevisiae 
2023-05-14 | GSE167915 | GEO
TranscriptomicsSplicing function of mitotic regulators links R-loop mediated DNA damage to tumor cell killing
We discovered that two mitotic regulators, BuGZ and Bub3, involved in splicing regulation during interphase 8 samples from primary Human foreskin fibroblast cells (HFFs) , 12 samples from TOV21G cells. Control siRNA. BuGZ siRNA or Bub3 siRNA were transfected for 48 h before sample collection. Cells ...
ORGANISM(S): Homo sapiens 
2015-04-11 | E-GEOD-67770 | biostudies-arrayexpress
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