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GenomicsRab8a restores diverse innate functions of CD11b+CD11c+ dendritic cells from aged mice
Rab8a restores diverse innate functions of CD11b+CD11c+ dendritic cells from aged mice
PRJNA1169897 | ENA
TranscriptomicsRab8a restores diverse innate functions of CD11b+CD11c+ dendritic cells from aged mice
Here, we demonstrate that Rab8a, a small GTPase, plays critical role in the functioning of dendritic cells (DCs) of aging host. Compared with the cells of young mice, CD11c+CD11b+ bone marrow derived dendritic cells (BMDCs) of aged mice generated a diminished type I IFN response when stimulated with...
ORGANISM(S): Mus musculus 
2024-10-14 | GSE279003 | GEO
UnknownMyosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.
Not available
S-EPMC1949367 | biostudies-literature
UnknownRab8a localisation and activation by Toll-like receptors on macrophage macropinosomes.
Not available
S-EPMC6304745 | biostudies-literature
TranscriptomicsMutations in LRRK2 linked to Parkinson’s disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson’s disease (PD) while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro and in vivo. The small GTPase Rab8a is a LRRK2 ki...
ORGANISM(S): Mus musculus 
2021-10-29 | GSE186559 | GEO
UnknownGuanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling.
Not available
S-EPMC7781844 | biostudies-literature
GenomicsMutations in LRRK2 linked to Parkinson’s disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
Mutations in LRRK2 linked to Parkinson’s disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
PRJNA774526 | ENA
UnknownRab8a regulates the exocyst-mediated kiss-and-run discharge of the Dictyostelium contractile vacuole.
Not available
S-EPMC3315810 | biostudies-literature
UnknownParkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Not available
S-EPMC5778812 | biostudies-literature
UnknownGPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway.
Not available
S-EPMC11761205 | biostudies-literature
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