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TranscriptomicsEffect of Rac1 haploinsufficiency on the gene expression profile of mouse endothelial cells
The therapeutic potential of neurotrophic factors has been hampered by their inability to achieve adequate tissue penetration. Brain blood vessels, however, could be an alternative target for neuro-salvage therapies by virtue of their close proximity to neurons. Here we show that hemizygous deletion...
ORGANISM(S): Mus musculus 
2009-03-15 | E-GEOD-15003 | biostudies-arrayexpress
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
ProteomicsIdentification of the cross-linked ELMO1-DOCK5-Rac1 complex.
The ELMO1-DOCK5-Rac1 complex is a dimer of heterotrimers centered on a homodimer of the DOCK5 DHR-2 domain. We analyzed the ELMO1-DOCK5-Rac1 complex by cross-linking mass spectrometry and identified intermolecular cross-links between Rac1, ELMO1, and DOCK5.
ORGANISM(S): Homo Sapiens (human) 
2021-05-25 | PXD026097 | JPOST Repository
TranscriptomicsRac1-Induced Connective Tissue Growth Factor regulates Connexin 43 and N-Cadherin Expression in Atrial Fibrillation
Objectives: We studied the signal transduction of atrial structural remodelling that contributes to the pathogenesis of atrial fibrillation (AF). Backround: Fibrosis is a hallmark of arrhythmogenic structural remodelling but the underlying molecular mechanisms are incompletely understood. Methods: W...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-14975 | biostudies-arrayexpress
ProteomicsCrosslinking MS of Elmo1,Dock5,Rac1 and RhoG complexes
Crosslink mass spectrometry of Elmo1,Dock5,Rac1 and RhoG complexes using BS3 crosslinker.
ORGANISM(S): Homo Sapiens (human) 
2025-01-18 | PXD048862 | JPOST Repository
TranscriptomicsSilcening RAC1 expression suppresses the proliferation of colon cancer cells by inducing gene differentially expressed.
In this study,RAC1 expression was silenced by RNA interference in colon cancer cell lines, and investigate the correlation between RAC1 expression and colon cancer proliferation,and differential expressed genes were analized by gene assay and qPCR technologe.The proliferation and colony formation ab...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-78093 | biostudies-arrayexpress
TranscriptomicsDNA microarray analysis using murine cerebellum at P6
We analysed genes upregulated or down regulated by double deletion of Rac1 and Rac3 (Rac1/Rac3-DKO) in cerebellar granule neurons compared with control, using the external granule layer (EGL) dissected from Rac1/Rac3-DKO cerebellum at P6. Rac1-KO mouse is an inducible knockout, in which Rac1 is spe...
ORGANISM(S): Mus musculus 
2017-05-16 | E-MTAB-5681 | biostudies-arrayexpress
TranscriptomicsLocalized Rho GTPase Activation Regulates RNA Dynamics and Compartmentalization in Tumor Cell Protrusions
mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, and deregulated control of protein translation is associated with tumor malignancy. We show here that activated RhoA, but not Rac1, is enriched in pseudopodia of MSV-MDCK-IN...
ORGANISM(S): Canis lupus familiaris 
2010-05-18 | E-GEOD-13253 | biostudies-arrayexpress
TranscriptomicsTranscriptome of K14 V12 Rac1 mice
Wholeskin from transgenic mice overexpressing epidermal specific (K14) activated mutant (V12) Rac1 analyzed with Illumina MouseRef8 v2 Gene Expression arrays Three V12 Rac1 7 day old pups compared to three 7 day old litter-mate controls
ORGANISM(S): Mus musculus 
2016-06-13 | E-GEOD-71683 | biostudies-arrayexpress
GenomicsMeiotic crossover landscape within RAC1 disease resistance gene
To study recombination at the fine-scale, we used high-throughput sequencing of 300 to 1,000 crossovers within the RAC1 R gene hotspot. This revealed focused intragenic crossovers, overlapping exons encoding the TIR, NBS and LRR domains. To examine the role of recombination pathways, we repeated thi...
ORGANISM(S): Arabidopsis thaliana 
2018-07-01 | E-MTAB-6333 | biostudies-arrayexpress
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