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TranscriptomicsMacrophage-Expressed Perforins Mpeg1 and Mpeg1.2 Have an Anti-Bacterial Function in Zebrafish
Macrophage expressed gene 1 (MPEG1) encodes an evolutionary conserved protein with a predicted Membrane Attack Complex/Perforin domain associated with host defence against invading pathogens. In vertebrates, MPEG1 is an integral membrane protein of macrophages, but how it contributes to the macropha...
ORGANISM(S): Danio rerio 
2014-09-01 | E-GEOD-54885 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection
Salmonella enterica serovar Typhimurium (S. typhimurium) bacteria cause an inflammatory and lethal infection in zebrafish embryos. To characterize the embryonic innate host response at the transcriptome level, we have extended and validated previous microarray data by Illumina next-generation sequen...
ORGANISM(S): Danio rerio 
2010-10-25 | E-GEOD-22472 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model of melanome secreting different amounts of histidine
We previously showed that transgenic enhancement of histamine production in B16-F10 melanomas strongly supports tumor growth in C57Bl/6 mice (Cancer Res, 2005 Pos et al.). In this array experiment, gene expression profiles of transgenic mouse melanomas, secreting different amounts of histamine, were...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8541 | biostudies-arrayexpress
TranscriptomicsMycobacterium marinum chronic infection of adult zebrafish
Novel high-throughput deep sequencing technology has dramatically changed the way that the functional complexity of transcriptomes can be studied. Here we report on the first use of this technology to gain insight into the wide range of transcriptional alterations that are associated with an infecti...
ORGANISM(S): Danio rerio 
2009-06-29 | E-GEOD-14782 | biostudies-arrayexpress
TranscriptomicsTranscriptomic approaches in the zebrafish model for tuberculosis – insights into host- and pathogen-specific determinants of the innate immune response
Both embryonic and adult zebrafish Mycobacterium marinum infection studies have contributed to our knowledge of the development and function of tuberculous granulomas, which are typical for mycobacterial pathogenesis. In this review we discuss how transcriptome profiling studies have helped to chara...
ORGANISM(S): Danio rerio 
2016-06-01 | E-GEOD-76499 | biostudies-arrayexpress
UnknownAnalysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
Not available
S-EPMC4564951 | biostudies-literature
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