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ProteomicsRAD54L2 mediates a novel mechanism to counter TOP2-DNA adducts
The catalytic cycle of topoisomerase 2 (TOP2) enzymes proceeds via a transient DNA double-strand break (DSB) intermediate termed the TOP2 cleavage complex (TOP2cc), in which the TOP2 protein is covalently bound to DNA. Anti-cancer agents such as etoposide operate by stabilising TOP2ccs, ultimately g...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046611 | Pride
Cancer Top2-dna adducts Etoposide Rad54l2 
UnknownRAD54L2 counters TOP2-DNA adducts to promote genome stability.
Not available
S-EPMC10699776 | biostudies-literature
UnknownImpact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population.
Not available
S-EPMC9670636 | biostudies-literature
UnknownRAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons.
Not available
S-EPMC10699775 | biostudies-literature
UnknownThe BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges.
Not available
S-EPMC11894219 | biostudies-literature
UnknownThe TRAF3-DYRK1A-RAD54L2 complex maintains ACE2 expression to promote SARS-CoV-2 infection.
Not available
S-EPMC11092330 | biostudies-literature
UnknownThe BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
Not available
S-SCDT-10_1038-S44319-025-00374-Z | biostudies-other
UnknownEstrogen associates with female predominance in Xp11.2 translocation renal cell carcinoma.
Not available
S-EPMC10105720 | biostudies-literature
UnknownIrradiation-Induced Upregulation of miR-711 Inhibits DNA Repair and Promotes Neurodegeneration Pathways.
Not available
S-EPMC7432239 | biostudies-literature
UnknownGenome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML.
Not available
S-EPMC10182178 | biostudies-literature
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