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MetabolomicsBerberine alleviates radiation-induced lung injury through promoting microbiota-derived inosine via gut-lung axis

Radiation-induced lung injury (RILI) is a major complication of thoracic radiotherapy. A previous study has indicated an association between berberine (BBR) and reduced incidence of RILI. However, the underlying mechanisms remain unknown. Here we validated the radioprotective role of BBR in mouse...

2025-05-14 | MTBLS12391 | MetaboLights
MetabolomicsFecal Microbiota Transplantation Restores Gut Homeostasis and Enhances ER-Phagy to Mitigate Radiation-Induced Lung Injury

Radiation-induced lung injury (RILI) is a severe side effect of radiation therapy, characterized by lung tissue damage, inflammation, and organ dysfunction. Although fecal microbiota transplantation (FMT) has shown potential in alleviating radiation-induced damage, its underlying mechanisms ...

2026-01-05 | MTBLS12699 | MetaboLights
MetabolomicsMechanism of Blueberry Anthocyanins in Ameliorating Radiation-Induced Intestinal Injury through Gut Microbiota Modulation
Radiation-induced intestinal injury denotes structural and functional impairment of the intestines resulting directly or indirectly from ionising radiation, such as that employed in radiation therapy for malignant tumours in the abdominal or pelvic regions, within the treatment area. It is a prevale...
2026-05-29 | MTBLS14609 | MetaboLights
ClinicalPrediction of the Chronicization of Radiation-induced Acute Intestinal Injury
Our team has constructed a prediction model based on the expression level of immune factors (PD-L1, PD-1, CTLA4, Siglec15) to predict the chronicization of radiation-induced acute intestinal injury (RAII) and verified the predictive efficacy of the system in retrospective studies. This clinical stud...
9985 | ecrin-mdr-crc
ClinicalPrediction of Radiation-induced Late Intestinal Injury
Our team has constructed a prediction model based on the phase separation level of DNA repair factors (MRNIP、NONO、NOP53) to predict radiation-induced late intestinal injury (RLII) and verified the predictive efficacy of the system in retrospective studies. This clinical study intends to further pros...
9987 | ecrin-mdr-crc
TranscriptomicsA translatable predictor of human radiation injury
The development of a biodosimetric assay based on the combined gene expression analysis of ex vivo-irradiated human peripheral blood (PB) and humans treated with total body irradiation has been developed. Gene expression profile signature of human radiation injury into a rapid and high-throughput c...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-58613 | biostudies-arrayexpress
ProteomicsStudy of molecular mechanisms in lung injury due to ultra-high and conventional dose rate pulsed radiation based on 4D-DIA proteomics
Objective: To investigate the mechanism of ultra-high dose rate pulsed radiation in radiation-induced lung injury (RILI), providing an experimental and theoretical basis for the application of FLASH-RT in radiotherapy. Methods: C57BL/6J mice were randomly divided into three groups: a sham group, a F...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD057784 | Pride
Radiation-induced lung injury  ultra-high dose rate  flash radiotherapy  fibrosis  flash effect 
GenomicsLycopene Ameliorates Ionizing Radiation-Induced Intestinal Injury
Lycopene Ameliorates Ionizing Radiation-Induced Intestinal Injury
PRJNA1172116 | ENA
ClinicalPrediction of the Chronicization of Radiation-induced Acute Intestinal Injury Based on the Expression Level of lncRNA
Our team has constructed a prediction model based on the expression level of lncRNA (lncRNA-UCID、NEAT1、ciRS-7) to predict the chronicization of radiation-induced acute intestinal injury (RAII) and verified the predictive efficacy of the system in retrospective studies. This clinical study intends to...
9986 | ecrin-mdr-crc
GenomicsRadiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation
Radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation
PRJNA1177799 | ENA
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