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ProteomicsTemporal profiling of redox-dependent heterogeneity in single cells
Cellular redox status affects diverse cellular functions, including proliferation, protein homeostasis, and aging. Thus, individual differences in redox status can give rise to distinct sub-populations even among cells with identical genetic backgrounds. Here, we have created a novel methodology to ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-06-18 | PXD009443 | Pride
Yeast Redox 
ProteomicsRemodeling of the focal adhesion complex by hydrogen-peroxide- induced senescence
Cellular senescence is a phenotype characterized by cessation of cell division, which can be caused by exhaustive replication or environmental stress. It is involved in age-related pathophysiological conditions and affects both the cellular cytoskeleton and the prime cellular mechanosensors, focal a...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-06 | PXD041766 | Pride
Lc-ms Oxidation Senescence 3t3 cell line 
ProteomicsCdc48’s interactions play a role in the cellular oxidative response in an aging-dependent manner
The cellular redox status has long been linked to different cellular functions, including protein quality control (PQC) and aging. The prominent molecular machine Cdc48 (p97/VCP in mammals) is one of the key players involved in PQC, shuttling misfolded proteins to degradation. Through a range of N-t...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-28 | PXD045122 | Pride
Redox Yeast Aging 
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