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TranscriptomicsTrim24 knock down in the 2i-state of the mouse ES cells
Differentially expressed genes were determined by single-end sequencing (stranded protocol) following Trim24 and/or p53 knock down in the mouse ES cells grown in 2i media. Triplicates were generated for treatment and control samples but for p53 knock down (duplicate).
ORGANISM(S): Mus musculus 
2017-11-08 | E-MTAB-4893 | biostudies-arrayexpress
ProteomicsStudying the core circuitry of pluripotency by selective isolation of chromatin-associated proteins
Here we have developed a method to identify chromatin-bound partners of a protein of interest by selective isolation of chromatin-associated proteins (SICAP) followed by mass spectrometry. We applied SICAP to identify chromatin-binding proteins associated to Oct4, Sox2 and Nanog in mouse embryonic s...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-19 | PXD003798 | Pride
Mass spectrometry Mouse embryonic stem cell Chromatin Sicap 
ProteomicsProteins co-localized with RNA Pol2 in ALS patient-derived neural precursors
Deficiency of proteostasis and RNA metabolism are increasingly recognized as critical drivers of neurodegenerative diseases. In this study, we focused on RNA polymerase II (Pol2) as the converging point of these two elements to understand how transcriptional machinery is affected by ALS-associated V...
ORGANISM(S): Homo Sapiens (human) 
2023-03-02 | PXD034483 | JPOST Repository
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