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ProteomicsQuantitative proteomics of cold adaptation of the Antarctic archaeon Halohasta litchfieldiae and Halorubrum lacusprofundi
Halohasta litchfieldiae and Halorubrum lacusprofundi are important members of Deep Lake in Antarctica, representing ~44% (the most abundance) and ~10% (the 3rd most abundance) of the lake population. Deep Lake is in the Vestfold Hills, East Antarctica (68°33’36.8S, 78°11’48.7E) and is 36 m deep, mon...
ORGANISM(S): Halohasta litchfieldiae Halorubrum lacusprofundi ATCC 49239 
2017-02-27 | PXD005076 | Pride
Antarctic microorganism  psychrophile  archaea  itraq  cold adaptation 
ProteomicsQuantitative proteomics of biofilm formation of the Antarctic archaeon Halorubrum lacusprofundi
Halorubrum lacusprofundi is an important member of Deep Lake in Antarctica, representing ~10% of the lake population (DeMaere et al., 2013). Deep Lake is in the Vestfold Hills, East Antarctica (68°33’36.8S, 78°11’48.7E) and is 36 m deep, monomictic, and perennially cold (down to -20°C) (DeMaere et a...
ORGANISM(S): Halorubrum lacusprofundi ATCC 49239 
2016-12-13 | PXD004202 | Pride
Antarctic microorganism  psychrophile  archaea  itraq 
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
ProteomicsMetaproteome, Deep Lake, Antarctica
Deep Lake is a hypersaline system in Antarctica (68°33’36.8S, 78°11’48.7E) that is so saline it remains liquid at –20°C (DeMaere et al 2013). The lake is dominated by haloarchaea, comprising a low-complexity community that differs greatly to warm-hot latitude hypersaline systems, is hierarchical st...
ORGANISM(S): environmental samples 
2015-07-21 | PXD001436 | Pride
Haloarchaea Metaproteomics Antarctica Hypersaline Deep lake 
ProteomicsGenome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Hypomethylating agents (HMAs) are frontline therapies effective at altering the natural course of Myelodysplastic Neoplasms (MDS). However, acquired resistance and treatment failure are hallmarks of HMA therapy. Developing effective and rational HMA-focused combinatorial therapies is challenging as...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD050539 | Pride
Myelodysplastic neoplasms Proteomics Genome-wide crispr-cas9 screen Sumo 
MetabolomicsNMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuroblastoma cell line
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
TranscriptomicsHuman memory T cells of the bone marrow are resting and maintain long-lasting memory
To compare human memory CD4+ T cell subsets in peripheral blood (PB) and bone marrow (BM) of healthy individuals at transcriptional level, we analyzed the global gene expression of ex vivo PB CD69- as well as BM CD69- and CD69+ memory CD4+ T cells from 4 paired PB and BM samples. The gene expression...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-50677 | biostudies-arrayexpress
UnknownVirophage control of antarctic algal host-virus dynamics.
Not available
S-EPMC3076838 | biostudies-literature
UnknownAn integrative study of a meromictic lake ecosystem in Antarctica.
Not available
S-EPMC3105772 | biostudies-literature
UnknownQuantitative proteomics of delirium cerebrospinal fluid.
Not available
S-EPMC4259987 | biostudies-literature
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