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Proteomics2019 Brecht et al. RAG1 vAbl BioID LC-MS/MS
To identify mechanisms that regulate V(D)J recombination, we used proximity-dependent biotin identification to analyze the interactomes of full length and truncated forms of RAG1 in pre-B cells. This revealed an association of RAG1 with numerous nucleolar proteins in a manner dependent on amino acid...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-02 | PXD016221 | Pride
Pre b cell Vabl cell V(d)j recombination Bioid Rag1 
GenomicsThe In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
The critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination signal sequences flanking antigen receptor V, D, and J gene segments, has not previously been characterized in vivo. Here we demonstrate that RAG protein binding occurs in a highly focal manner to a small reg...
ORGANISM(S): Mus musculus 
2010-04-19 | E-GEOD-21207 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine from wildtype B6, Rag1-/- B6 and Rag1-/- B6 mice harboring the 225.4 IgA producing hybridoma after infection with Bacteroides thetaiotaomicron
Wildtype B6, Rag1-/- B6 and Rag1-/- B6 mice harboring the 225.4 IgA producing hybridoma were colonized for 10 days with Bacteroides thetaiotaomicron Experiment Overall Design: Distal small intestine segments were snap frozen immediately after the mice were sacrificed, and small intestine divided int...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9018 | biostudies-arrayexpress
TranscriptomicsGenetic and transcriptome analyses of early T-cell checkpoint failure and leukemia initiation in Rag1-deficient NOD mice
Both immunodeficient and wild type NOD mice exhibit defects in control of early T-cell development in the thymus. We show that Rag1-deficient NOD mice fail to enforce both the b-selection checkpoint and an earlier T-cell commitment checkpoint, based on genome-wide genetic and transcriptome analyses....
ORGANISM(S): Mus musculus 
2013-03-07 | E-GEOD-40688 | biostudies-arrayexpress
GenomicsRAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2
The RAG1/RAG2 endonuclease initiates V(D)J recombination at antigen receptor loci but also binds to thousands of places outside of these loci. RAG2 localizes directly to lysine 4 trimethylated histone 3 (H3K4me3) through a PHD finger. The relative contribution of RAG2-dependent and RAG1-intrinsic ...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-84052 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Rag1 mutant and Rag1/Ezh2 double mutant double negative thymocytes
Expression profiles from Rag1 mutant and Rag1/Ezh2 double mutant double negative thymocytes
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1565 | biostudies-arrayexpress
TranscriptomicsGene expression profile after Spring Viraemia Carpae Virus (SVCV) infection in zebrafish mutants rag1 -/- versus wt
Immune responses in higher vertebrates are classically separated into innate and adaptive (or specific) immunity. However, important gaps of knowledge about how adaptive responses are generated in lower vertebrates still remain unsolved. In order to explore the relative importance of adaptive and in...
ORGANISM(S): Danio rerio 
2015-05-10 | E-GEOD-54096 | biostudies-arrayexpress
GenomicsRAG1-Independent Atypical B Cell Development in Chickens: Redefining the Role of RAG1 in Avian Immunology
RAG1-Independent Atypical B Cell Development in Chickens: Redefining the Role of RAG1 in Avian Immunology
PRJNA1245439 | ENA
TranscriptomicsTranscriptional profiling of rag1 deficient (rag1-/-) and rag1 heterozygous (rag1+/-) zebrafish kidney and intestine
Four dual hybridizations of rag1 deficient (rag1-/-) and rag1 heterozygous (rag1+/-) zebrafish cRNAs from kidney and intestine. Keywords: Gene knockout
ORGANISM(S): Danio rerio 
2009-01-05 | GSE12655 | GEO
GenomicsRAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2
RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2
PRJNA327870 | ENA
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