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ProteomicsArchitecture of human Rag GTPase heterodimers and their complex with mTORC1
The Rag GTPases recruit the master kinase mTORC1 to lysosomes to regulate cell growth and proliferation in response to amino acid availability. The nucleotide state of Rag heterodimers is critical for their association with mTORC1. Our cryo-EM structure of RagA/RagC in complex with mTORC1 shows the ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-11 | PXD015778 | Pride
Raga Ragc Hdx-ms Mtorc1 
GenomicsEffect of feeding on gene expression in WT, raga-1, and rsks-1 mutant animals
Effect of feeding on gene expression in WT, raga-1, and rsks-1 mutant animals
PRJNA1138410 | ENA
UnknownRaga Bhairavi in virtual reality reduces stress-related psychophysiological markers.
Not available
S-EPMC11496638 | biostudies-literature
UnknownRAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation.
Not available
S-EPMC9950044 | biostudies-literature
UnknownRagA, but not RagB, is essential for embryonic development and adult mice.
Not available
S-EPMC4035553 | biostudies-literature
TranscriptomicsEffect of feeding on gene expression in WT, raga-1, and rsks-1 mutant animals
After subjecting WT, raga-1, and rsks-1 (S6K) animals to this growth arrest, we compared them by RNA sequencing (RNA-seq) to a group that was released from arrest by feeding for four hours
ORGANISM(S): Caenorhabditis elegans 
2024-11-20 | GSE272718 | GEO
UnknownBrain Specific RagA Overexpression Triggers Depressive-Like Behaviors in Mice via Activating ADORA2A Signaling Pathway.
Not available
S-EPMC11615787 | biostudies-literature
GenomicsNociceptor translational profiling reveals the RagA-mTORC1 network as a critical generator of neuropathic pain
Nociceptor translational profiling reveals the RagA-mTORC1 network as a critical generator of neuropathic pain
PRJNA454562 | ENA
TranscriptomicsNociceptor translational profiling reveals the RagA-mTORC1 network as a critical generator of neuropathic pain
Pain sensing neurons, nociceptors, are key drivers of neuropathic pain. We used translating ribosome affinity purification (trap) to comprehensively characterize up- and down-regulated mRNA translation in Scn10a-positive nociceptors in chemotherapy-induced neuropathic pain. We provide evidence that ...
ORGANISM(S): Mus musculus 
2018-08-01 | GSE113941 | GEO
UnknownManipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1.
Not available
S-EPMC2877737 | biostudies-literature
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